Journal ArticleDOI
A Controlled Study of Lithium vs. Chlorpromazine in Acute Schizophrenics
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TLDR
A previous double-blind controlled evaluation of lithium and chlorpromazine in both manic and schizo-affective individuals carried out in this unit indicated that 85 per cent of the schizo -affectives showed a worsening of thought disorder when treated with lithium carbonate, the majority developing symptoms of an acute brain syndrome.Abstract:
Twenty-one newly hospitalized schizophrenic patients were given chlorpromazine (10 patients) or lithium carbonate (11 patients) in a double-blind controlled fashion. The results unequivocally indicate superior treatment efficacy under chlorpromazine in either reducing symptom severity or bringing about illness remission; lithium often contributed to further decompensation in schizophrenic symptomatology. Indeed, lithium may be detrimental to schizophrenics in that these patients run a greater liability of developing neurotoxicity at modest lithium doses and blood levels.read more
Citations
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Journal ArticleDOI
Diagnosis in schizophrenia and manic-depressive illness: a reassessment of the specificity of 'schizophrenic' symptoms in the light of current research.
TL;DR: It is concluded that most so-called schizophrenic symptoms, taken alone and in cross section, have remarkably little, if any, demonstrated validity in determining diagnosis, prognosis, or treatment response in psychosis.
Journal ArticleDOI
The Stages of Mania: A Longitudinal Analysis of the Manic Episode
TL;DR: The progression of symptoms during an acute manic episode was studied retrospectively in 20 bipolar manic-depressive patients whose diagnosis was reconfirmed at follow-up, and the advantages of using a longitudinal view of a psychotic episode as a diagnostic tool are discussed.
Journal ArticleDOI
Prolactin Responses to Neuroleptics in Normal and Schizophrenic Subjects
Peter H. Gruen,Edward J. Sachar,Gerhard Langer,Norman Altman,Marvin Leifer,Andrew G. Frantz,Frieda S. Halpern +6 more
TL;DR: Relative prolactin-stimulating potency in humans of chlorpromazine, thioridazine, trifluoperazine, butaperazine, and haloperidol correlated well with their relative clinical potencies.
Journal ArticleDOI
A review of the biochemical and neuropharmacological actions of lithium.
A. J. Wood,Guy M. Goodwin +1 more
TL;DR: The biochemical and neuropharmacological data relating to the therapeutic effects of lithium are reviewed and efforts are made to identify profitable areas for further research.
References
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Journal ArticleDOI
Lithium As a Prophylactic Agent: Its Effect Against Recurrent Depressions and Manic-Depressive Psychosis
TL;DR: In order to demonstrate prophylactic drug action in a disorder such as manicdepressive psychosis, which is characterized by a capricious and largely unpredictable course, one must study a large number of patients who have a sufficiently high risk of relapse and who are observed for relapse.
Journal ArticleDOI
The Use of Lithium Salts in Affective Disorders
TL;DR: Since the original observations in Australia by Cade and Noack and Trautner (1951) on the use of lithium salts in psychiatric practice there has been a modest but steady stream of publications on the subject, and the most persistent investigator has been Schou in Denmark.
Journal ArticleDOI
Controlled evaluation of lithium and chlorpromazine in the treatment of manic states: An interim report *
TL;DR: An interim report of a double blind study of the action of lithium and chlorpromazine in manic states is presented and a control group of schizo-affective patients has been included.
Journal ArticleDOI
Imipramine and Thioridazine in Depressed and Schizophrenic Patients: Are There Specific Antidepressant Drugs?
TL;DR: Summing across both patient samples, thioridazine was found significantly superior to imipramine in a number of symptom areas, while imipramsine was superior only in reducing motor retardation.