Open AccessJournal Article
A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma.
TLDR
There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in patients and the combination was shown to produce greater and longer lasting bronchodilation than either drug alone.Abstract:
The combination of nebulized atropine methylnitrate (AMN) and a beta-agonist has been shown to produce greater and longer lasting bronchodilation than either drug alone. We examined the efficacy of the combination in diminishing the "morning dipping" in PEFR in eight hospitalized but stable asthmatics. The patients received nebulized albuterol along with either AMN (AMN + ALB) or placebo (ALB) in a random double-blind cross-over fashion at 10 PM on four nights. PEFR and FEV1 were recorded at 6 PM, 10 PM, and 6 AM before the administration of bronchodilators. There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in these patients.read more
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Journal ArticleDOI
Anticholinergic agents for chronic asthma in adults
TL;DR: No justification is provided for routinely introducing anticholinergic agents as part of add-on treatment for patients whose asthma is not well controlled on standard therapies and any future trials might draw on the messages derived from this review.
Book ChapterDOI
Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
Prasanta Kumar Dey,Amit Kundu,Anoop Kumar,Meenakshi Gupta,Byung Mu Lee,Tejendra Bhakta,Suvakanta Dash,Hyung Sik Kim +7 more
TL;DR: This chapter highlights the phytochemistry of the main representatives among the diverse group of alkaloids, and focuses on their extraction, purification, fractionation, identification, and quantification procedures.
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Anticholinergic therapy for chronic asthma in children over two years of age
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The Use of Anticholinergics in Asthma
TL;DR: The pharmacological and neurological properties of anticholinergics make them excellent modalities for treatment of asthma, and their use in acute asthma is more controversial.