Journal ArticleDOI
Acute hepatitis associated with the use of an herbal supplement (Polygonum multiflorum) mimicking iron-overload syndrome.
Ashley R. Laird,Nina Ramchandani,Emil M. deGoma,Bharathi Avula,Ikhlas A. Khan,Neil Gesundheit +5 more
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TLDR
Five patients with acute hepatitis associated with the use of Polygonum multiflorum have suffered from acute hepatitis following treatment with these herbal supplements.Abstract:
To the Editor:A Chinese herb, Polygonum multiflorum, known as Shou Wu Pian and He Shou Wu root, is an ingredient of many herbal supplements promoted to treat balding, dizziness, prostatitis, and constipation. Five patients with acute hepatitis associated with the use of Polygonum multiflorum have prread more
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Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb.
Kyoung Ah Jung,Hyun Ju Min,Seung Suk Yoo,Hong Jun Kim,Su Nyoung Choi,Chang Yoon Ha,Hyun Jin Kim,Tae Hyo Kim,Woon Tae Jung,Ok Jae Lee,Jong Sil Lee,Sang Goon Shim +11 more
TL;DR: Patients diagnosed with toxic hepatitis following ingestion of Polygonum multiflorum Thunb could be hepatotoxic and could lead to severe drug-induced liver injury, and even death.
Journal ArticleDOI
Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps.
Rolf Teschke,Axel Eickhoff +1 more
TL;DR: Encouraging steps in the field of herbal hepatotoxicity focus on introducing analytical methods that identify cases of intrinsic liver injury caused by pyrrolizidine alkaloids, and on omics technologies, including genomics, proteomics, metabolomics, and assessing circulating micro-RNA in the serum of some patients with intrinsic hepatot toxicity.
Journal ArticleDOI
Hepatotoxicity of herbal and dietary supplements: an update
Felix Stickel,Daniel Shouval +1 more
TL;DR: Herbal and dietary supplements have been used for health-related purposes since more than 5000 years, and their application is firmly anchored in all societies worldwide, but their use is predominantly based on belief and hope.
Journal ArticleDOI
Application of metabonomic analytical techniques in the modernization and toxicology research of traditional Chinese medicine.
TL;DR: It is believed that with the further development of metabonomic analytical techniques, especially multi‐analysed techniques, metabonomics will greatly promote TCM toxicity research and be beneficial to the modernization of TCM in terms of extending the application of modern means in the TCM safety assessment, assisting the formulation ofTCM safety norms and establishing the international standards indicators.
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Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation
Christian Frenzel,Rolf Teschke +1 more
TL;DR: Future strategies should focus on RUCAM based causality assessment in suspected HILI cases and more regulatory efforts to provide all herbal medicines and herbal dietary supplements used as medicine with strict regulatory surveillance, considering them as herbal drugs and ascertaining an appropriate risk benefit balance.
References
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Journal ArticleDOI
Management of hemochromatosis. Hemochromatosis Management Working Group.
James C. Barton,Sharon M. McDonnell,Paul C. Adams,Pierre Brissot,Lawrie W. Powell,Corwin Q. Edwards,James D. Cook,Kris V. Kowdley +7 more
TL;DR: In this article, therapeutic phlebotomy is used to remove excess iron and maintain low normal body iron stores, and it should be initiated in men with serum ferritin levels of 300 microg/L or more and in women with seri cation level of 200 microg /L, regardless of the presence or absence of symptoms.
Journal ArticleDOI
Management of hemochromatosis
James C. Barton,Sharon M. McDonnell,Paul C. Adams,Pierre Brissot,Lawrie W. Powell,Corwin Q. Edwards,James D. Cook,Kris V. Kowdley +7 more
TL;DR: Although iron overload often develops in patients with hemochromatosis, the demonstration of hepatic or systemic iron overload and associated complications is not needed to confirm the diagnosis and the quantity of iron removed by therapeutic phlebotomy is a valuable retrospective indicator of the severity of iron overload.
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High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure.
Jason d. Estes,David Stolpman,Ali J. Olyaei,Christopher L. Corless,John M. Ham,Jonathan M. Schwartz,Susan L. Orloff +6 more
TL;DR: Herbal and dietary supplements were potential hepatotoxins in a high proportion of patients with FHF at this institution, and increased regulatory oversight of their use is strongly urged.
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Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum.
TL;DR: This is the first case in Australia of acute hepatitis associated with the Chinese herbal medicine Shou‐Wu‐Pian, prepared from Polygonum multiflorum, and liver biopsy was consistent with a toxic reaction.
Journal Article
Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum
TL;DR: Hepatitis developed in a 31-y-old pregnant Chinese woman after consumption of Shou-Wu-Pian, a proprietary Chinese medicine prepared from Polygonum multiflorum, commonly available in the Orient and China towns in western countries.