Acute Zinc Toxicity in Haemodialysis
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TLDR
Experimental haemodialyses of dogs against small concentrations of zinc showed a disproportionate rise in plasma zinc and possible uptake of zinc by the liver, and a country patient on home haemmodialysis was found to have severe anaemia with raised plasma and erythrocyte zinc concentrations.Abstract:
A country patient on home haemodialysis suffered acute nausea, vomiting, and fever during dialyses when she used water stored in a galvanized tank. She subsequently was found to have severe anaemia with raised plasma and erythrocyte zinc concentrations. Intercurrent hospital haemodialyses and subsequent home dialyses with deionized water were symptom-free. Experimental haemodialyses of dogs against small concentrations of zinc showed a disproportionate rise in plasma zinc and possible uptake of zinc by the liver.read more
Citations
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Normal levels of trace elements in human blood plasma or serum
Jacques Versieck,Rita Cornelis +1 more
TL;DR: Much work remains to be done to establish the normal levels of most trace elements in blood plasma or serum of apparently healthy individuals, and the development of adequate measures for contamination control is the most important prerequisite.
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Current status of zinc in health and disease states
P J Aggett,J T Harries +1 more
TL;DR: The biological importance of zinc was first discovered when Raulin (1869) demonstrated that it was necessary for the growth of Aspergillus niger and a more profound deficiency state became apparent when Moyanhan and Barnes (1973) showed that treatment with zinc induced a complete and rapid clinical remission in a patient with acrodermatitis enteropathica.
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Reversal of uræmic impotence by zinc
TL;DR: In eight impotent haemodialysed men with low plasma-zinc levels sexual function, including potency, frequency of intercourse, libido, and plasma testosterone, was determined before and after therapy with zinc or placebo.
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Zinc supplementation in critically ill patients: a key pharmaconutrient?
Daren K. Heyland,Daren K. Heyland,Naomi E. Jones,Naomi E. Jones,Natalie Z. Cvijanovich,Hector R. Wong +5 more
TL;DR: A rationale for zinc supplementation as a potential therapeutic agent in critically ill patients is provided by describing its role in health and disease, conducting a systematic review of current randomized trials in critical care, considering optimum route and dose of administration, and making recommendations for future research.
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Zinc in human nutrition.
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References
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Plasma Steroid and Luteinizing Hormone Levels during Prostaglandin F2α Administration in Luteal Phase of Menstrual Cycle
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