Journal ArticleDOI
Adrenomedullary response to maximal stress in humans
TLDR
It is concluded that chronic, severe stress produces only moderate elevations of plasma epinephrine levels, whereas acute stress produces marked increases of plasmaEpinephrine that may reach the extraordinarily high level of 35.9 ng/ml, and under close medical monitoring, it is possible to survive with plasma Epinephrine concentrations as high as 273 ng/ML.About:
This article is published in The American Journal of Medicine.The article was published on 1984-11-01. It has received 188 citations till now. The article focuses on the topics: Epinephrine & Catecholamine.read more
Citations
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Journal ArticleDOI
The Influence of Hyperglycemia on Neurological Outcome in Patients with Severe Head Injury
Aristedis Rovlias,Serafim Kotsou +1 more
TL;DR: Early hyperglycemia is a frequent component of the stress response to head injury, a significant indicator of its severity, and a reliable predictor of outcome.
Journal ArticleDOI
Sympathetic Overstimulation During Critical Illness: Adverse Effects of Adrenergic Stress:
TL;DR: Potential therapeutic options to reduce excessive adrenergic stress comprise temperature and heart rate control, adequate use of sedative/analgesic drugs, and aiming for reasonable cardiovascular targets, adequate fluid therapy, use of levosimendan, hydrocortisone or supplementary arginine vasopressin.
Journal ArticleDOI
Epinephrine Produces a β-Adrenergic Receptor-Mediated Mechanical Hyperalgesia and In Vitro Sensitization of Rat Nociceptors
TL;DR: Consistent with the hypothesis that epinephrine produces hyperalgesia by a direct action on primary afferent nociceptors, it was found to sensitize small-diameter dorsal root ganglion neurons in culture and cause a potentiation of tetrodotoxin-resistant sodium current.
Journal ArticleDOI
Vasopressin Improves Vital Organ Blood Flow During Closed-Chest Cardiopulmonary Resuscitation in Pigs
Karl H. Lindner,Andreas W. Prengel,Ernst G. Pfenninger,Ingrid M. Lindner,Hans-Ulrich Strohmenger,Michael K. Georgieff,Keith G. Lurie +6 more
TL;DR: This study was designed to compare the effects of epinephrine with those of vasopressin on vital organ blood flow during closed-chest cardiopulmonary resuscitation (CPR) in a pig model of ventricular fibrillation.
References
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Journal ArticleDOI
Physiology and Pathophysiology of the Human Sympathoadrenal Neuroendocrine System
TL;DR: The sympathoadrenal system is the prototype neuroendocrine system and norepinephrine is released from axon terminals of sympathetic postganglionic neurons and deposited directly at innervated target cells.
Rates and Physiologic Thresholds for Metabolic and Hemodynamic Actions in Man
TL;DR: In this paper, 60-min intravenous epinephrine infusions at nominal rates of 0.1, 0.5, 1.0, 2.5 and 5.0 pg/min were performed in each of six normal human subjects.
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Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.
TL;DR: It is concluded that in human subjects: (a) the plasma epinephrine thresholds for its hemodynamic and metabolic actions lie within the physiologic range, (b) epine dopamine and norepinephrine accelerate their own metabolic clearance, and (c) epinphrine is 10 times more potent than nore Alpinephrine.
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The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man.
A J Garber,P. E. Cryer,Julio V. Santiago,Morey W. Haymond,Anthony S. Pagliara,David M. Kipnis +5 more
TL;DR: It seems probable that adrenergic mechanisms play a major role in the initiation of counter-regulatory responses to insulin-induced hypoglycemia in man.
Journal ArticleDOI
Plasma Norepinephrine and Epinephrine in Untreated Diabetics, During Fasting and After Insulin Administration
TL;DR: Plasma norepinephrine rose as blood glucose concentrations decreased even in diabetics in whom values had not reached hypoglycemic levels, and no correlation was observed between plasma epinephrine and increase in pulse rate during hypoglycemia.
Related Papers (5)
Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs.
R.V. Ditchey,J.A. Lindenfeld +1 more