Journal ArticleDOI
An epidemic of dengue on Tahiti associated with hemorrhagic manifestations.
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TLDR
During the course of an outbreak of dengue type 2 on the island of Tahiti, French Polynesia, severe hemorrhagic disease was observed in an unusual number of patients shortly after the onset of a febrile illness and 3 patients died.Abstract:
During the course of an outbreak of dengue type 2 on the island of Tahiti, French Polynesia, severe hemorrhagic disease was observed in an unusual number of patients shortly after the onset of a febrile illness. In at least 33 instances, these hemorrhages were severe enough to require hospitalization and 3 patients died. Gastrointestinal bleeding was the most common type of severe hemorrhage observed and gross hematuria was next most common. The available data suggested that most of the hemorrhagic episodes were etiologically related to dengue virus.read more
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Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century
TL;DR: There are many factors that have contributed to this emergence of epidemic dengue, but only three have been the principal drivers: urbanization, globalization and lack of effective mosquito control.
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The dengue viruses.
E A Henchal,J R Putnak +1 more
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Prospects for a dengue virus vaccine.
TL;DR: The unique immunological concerns in dengue virus vaccine development are discussed and the current prospects for the development of an acceptable vaccine are discussed, with a goal that is likely to be reached in the near future.
Journal ArticleDOI
Antibody-Dependent Enhancement of Infection and the Pathogenesis of Viral Disease
TL;DR: Evidence suggests that ADE reflects immunologic processes that occur in vivo, and more data are urgently needed on the mechanisms and determinants of ADE and on its alleged role in disease pathogenesis and in vaccine-associated phenomena.
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The Emperor's New Clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever.
TL;DR: This address is to review a scientific topic which has been of interest to me during the past few years and is especially appropriate for the site of the authors' gathering this year and for the bicentennial which their joint meeting commemorates.