Showing papers in "Virology in 1990"

TL;DR: The complete DNA sequence of the genome of vaccinia virus has been determined and several similarities to proteins of known function were discerned, but the function of the majority of proteins encoded by these open reading frames is as yet undetermined.

TL;DR: This work reports the first genetic evidence of the existence of a sylvatic cycle of dengue virus, which is clearly distinct from outbreak viruses, which seems to have evolved independently in West Africa.

TL;DR: This article showed that B/Yamagata/16/88-like viruses were more closely related to epidemic viruses from 1983 (B/USSR/100/83) than to more recent reference strains such as B/Victoria/2/87.

TL;DR: The strong conservation of both noncoding and coding nucleotide sequences indicates a high selective pressure on the primary structure of rabies virus genomic RNA.

TL;DR: This is the first direct demonstration that a CP mutation affects aphid transmissibility of a potyvirus.

TL;DR: The lentivirus caprine arthritis-encephalitis virus (CAEV) is closely related by nucleotide sequence homology to visna virus and other sheep lentiviruses and shows less similarity to the other animal and human lentivIRuses.

TL;DR: Results show that the specificity of leafhopper transmission from insect to plant resides with the coat protein, which is typical of ACMV infection.

TL;DR: It is concluded that latent phase transcription of HSV facilitates ganglionic reactivation and subsequent ocular shedding of the reactivated virus.

TL;DR: The types of receptors on the surfaces of human and other mammalian cells for 13 C-type and 7 D-type retrovirus strains were determined by interference to the formation of syncytia and the plating of viral pseudotypes.

TL;DR: Sequences in p80, the most homologous protein among pestiviruses, showed similarity to six sequence motifs found conserved in helicase-like proteins represented by eIF-4A, suggesting that pestivirus p80 may be bifunctional.

TL;DR: Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus has been performed and distinct clusters of amino acid substitutions conferring resistance to neutralization at each of the four previously defined antigenic sites have been identified.

TL;DR: The results support the hypothesis of Tuttleman et al. (1986a) that CCC DNA amplification in chronically infected cultures and, by inference, the mechanism of persistent infection involves primarily intracellular regulatory mechanisms.

TL;DR: Using an in vitro immunoprecipitation assay, domains in both 55K and p53 required for the interaction of the two proteins were mapped and mutations which prevented 55K-p53 binding were not more defective for transformation than other mutations which did not affect binding.

TL;DR: The inhibitory effect of dextran sulfate and its congeners on the interaction of the HIV gp120 with the cellular CD4 receptor can be ascribed to a specific binding ("shielding") of gp120.

TL;DR: The complete sequence of the genome of the cherry strain of tomato bushy stunt virus (TBSV), a member of the tombusvirus group, was determined and computer alignments of TBSV proteins with those of two other tombusviruses suggest greater relatedness among the members of this group than previously reported.

TL;DR: Of the six cDNAs cloned, only the 1480-bp E7 message has been observed in other HPV16-containing cell lines, and the presence of L1 transcripts, and an E2 repressor mRNA, although unexpected, may reflect the different origins of the W12 cell line.

TL;DR: It is concluded that chronic hepatitis cases positive for anti-HBe are associated with HBV variants containing an inactive pre-C region and hence cannot synthesize pre- C region-derived HBeAg, which may provide a molecular explanation for the continued viral replication despite presence of anti- HBe immunity.

TL;DR: The results indicate that mutations in ORFs AR1 and AL2 do not affect viral double-stranded DNA levels, although AR1 or AL2 mutants accumulate only small amounts of single-Stranded viral DNA (ssDNA).

TL;DR: The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (SF) cell cultures using a baculovirus vector and results indicate that SF cells have the capacity to trim N-glycans to trimannosyl cores and to further process these by the addition of fucose.

TL;DR: It is suggested that the cleavage of prM occurs in the acidic post-Golgi vesicles and is necessary to generate fully infectious virus.

TL;DR: A gene encoding an 18-kDa polypeptide located in the vaccinia virus HindIII C fragment was shown to be functionally equivalent to previously described host range gene (ORF K1L) spanning the HindIII K/M fragment junction.

TL;DR: The complete nucleotide sequences and translations of major open reading frames (ORF) of two distinct, infectious, proviral molecular clones of the bovine immunodeficiency-like virus (BIV), obtained from a single virus isolation, were determined and compared and suggest that BIV displays extensive genomic variation.

TL;DR: Evidence began to emerge that the function of wild-type ~53 might be to negatively regulate the growth of some cells and that p53 appears to act as a tumor suppressor gene under some circumstances (Mowat et al, 1985; Finlay et al., 1989; Baker et a/., 1989).

TL;DR: The complete nucleotide sequence of the genome of the dengue virus type 3 was determined and the genome organization was found to be the same as that of other flaviviruses.

TL;DR: Limited replication in macrophages is consistent with the total CNS virus content detected at any time during the persistent phase of the infection as well as the slow pace of the infections.

TL;DR: The order of the helicase motif and the nsP3 homology region in the RUB genome is reversed with respect to the alphavirus genome indicating that a genetic rearrangement has occurred during the evolution of these viruses.

TL;DR: The data indicate that the 294R and 116R proteins act in parallel to permit the accumulation of normal levels of unprocessed late viral RNA in the nucleus of infected cells, consistent with a role for the 496R/294R protein complex in mediating efficient transport of late messages from the nucleus to the cytoplasm and/or in maintaining the stability of those messages on reaching the cy toplasm.

TL;DR: Oligonucleotide fingerprints of the parent SA-14 and vaccine strain indicate that multiple genetic changes occurred during attenuation of the virus.

TL;DR: It is suggested that differences of 30% or more at the amino acid level in HA1 constitute separate subtypes, and H14 is one of the most recently diverged lineages while H8 and H12 branched off early during the evolution of the HA subtypes.

TL;DR: The classification of the human coronavirus 229E in a taxonomic cluster distinct from TGEV group is suggested because an antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronav virus.