Journal ArticleDOI
An evaluation of method reporting and use in clinical trials in dermatology.
TLDR
In a survey of 62 clinical trials published in four dermatology journals, recommended methodology was reported 41% of the time and there were no differences among journals in reporting methods used.Abstract:
• In a survey of 62 clinical trials published in four dermatology journals, recommended methodology was reported 41% of the time. Of the 62 trials, 31 were open drug trials and 27 were controlled trials. Forty-one percent of 13 recommended methodologic items were reported in these articles. The rate of reporting for these items ranged from 3% for power and method of randomization to 76% for loss to follow-up and the use of a control group. There were no differences among journals in reporting methods used. Investigators and editors are encouraged to improve the reporting and use of recommended methodology in clinical trials published in the dermatologic literature. ( Arch Dermatol 1985;121:1394-1399)read more
Citations
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Improving Doctors' understanding of statistics
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A systematic review of five systemic treatments for severe psoriasis.
TL;DR: Exclusion rate was high, mainly because of concomitant antipsoriatic therapy, outdated dosages or inadequate documentation, and Incidence of side‐effects per week was highest in the RET group and lowest in the phototherapy groups.
Journal ArticleDOI
How well are randomized controlled trials reported in the dermatology literature
Kayode Adetugbo,Hywel C Williams +1 more
TL;DR: There is the need for higher methodological quality in clinical trial reporting in dermatology journals and the adoption of the CONSORT (Consolidated Standards of Reporting Trials) statement and checklist for the reporting of trials should enhance the validity of and strengthen the evidence from clinical trials reports.
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Randomized Clinical Trials for Psoriasis 1977–2000: The EDEN Survey
Luigi Naldi,Åke Svensson,Thomas L. Diepgen,Peter Elsner,Jean-Jacques Grob,Pieter Jan Coenraads,Jan Nico Bouwes Bavinck,Hywel C Williams +7 more
TL;DR: An enormous range of treatments that have been evaluated for psoriasis over the examined period are identified and there is an urgent need to reset the research agenda focusing on long-term comparative RCTs.
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Pityriasis versicolor: a systematic review of interventions.
Stephanie W. Hu,Michael Bigby +1 more
TL;DR: Most topical and systemic treatments used for pityriasis versicolor are effective compared with placebo, and data suggest that longer durations of treatment and higher concentrations of active agents produce greater cure rates.
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The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials.
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Journal ArticleDOI
Reporting on methods in clinical trials
TL;DR: Survey of clinical trials published in the New England Journal of Medicine, the Lancet, and the British Medical Journal found information about statistical analyses, statistical methods used, and random allocation of subjects was reported, yet only 19 per cent reported the method of randomization.
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