T
Thomas C. Chalmers
Researcher at Harvard University
Publications - 166
Citations - 23583
Thomas C. Chalmers is an academic researcher from Harvard University. The author has contributed to research in topics: Randomized controlled trial & Clinical trial. The author has an hindex of 62, co-authored 166 publications receiving 23091 citations. Previous affiliations of Thomas C. Chalmers include City University of New York & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration.
Salim Yusuf,Salim Yusuf,David M. Zucker,David M. Zucker,E Passamani,P Peduzzi,T Takaro,Lloyd D. Fisher,J W Kennedy,Kathryn B. Davis,T Killip,Norris R,C Morris,V Mathur,Varnauskas Ed,Thomas C. Chalmers +15 more
TL;DR: A strategy of initial CABG surgery is associated with lower mortality than one of medical management with delayed surgery if necessary, especially in high-risk and medium- risk patients with stable coronary heart disease, and in low-risk patients, the limited data show a non-significant trend towards greater mortality with CABGs.
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The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials.
TL;DR: Concern for the probability of missing an important therapeutic improvement because of small sample sizes deserves more attention in the planning of clinical trials.
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A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction.
TL;DR: Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a timely fashion need access to better databases and new statistical techniques to assist them.
Journal ArticleDOI
Meta-analyses of randomized controlled trials.
TL;DR: It is concluded that an urgent need exists for improved methods in literature searching, quality evaluation of trials, and synthesizing of the results.
Journal ArticleDOI
Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction
Joseph Lau,Elliott M. Antman,Jeanette Jimenez-Silva,Bruce Kupelnick,Frederick Mosteller,Thomas C. Chalmers +5 more
TL;DR: Cumulative meta-analysis of therapeutic trials facilitates the determination of clinical efficacy and harm and may be helpful in tracking trials, planning future trials, and making clinical recommendations for therapy.