Open AccessJournal Article
Analysis of CT features of 15 Children with 2019 novel coronavirus infection/ 中华儿科杂志/ Analysis of CT features of 15 Children with 2019 novel coronavirus infection/ 中华儿科杂志
TLDR
The early chest CT images of children with 2019-nCoV infection are mostly small nodular ground glass opacities, and Dynamic reexamination of chest CT and nucleic acid are important.Abstract:
Objective@#To explore imaging characteristics of children with 2019 novel coronavirus (2019-nCoV) infection.@*Methods@#A retrospective analysis was performed on clinical data and chest CT images of 15 children diagnosed with 2019-nCoV. They were admitted to the third people’s Hospital of Shenzhen from January 16 to February 6, 2020. The distribution and morphology of pulmonary lesions on chest CT images were analyzed.@*Results@#Among the 15 children, there were 5 males and 10 females, aged from 4 to 14 years old. Five of the 15 children were febrile and 10 were asymptomatic on first visit. The first nasal or pharyngeal swab samples in all the 15 cases were positive for 2019-nCoV nucleic acid. For their first chest CT images, 6 patients had no lesions, while 9 patients had pulmonary inflammation lesions. Seven cases of small nodular ground glass opacities and 2 cases of speckled ground glass opacities were found. After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. Among them, chest CT images showed less lesions in 2 cases, no lesion in 3 cases, and no improvement in 1 case. Other 9 cases were still positive in a second nucleic acid test. Six patients showed similar chest CT inflammation, while 3 patients had new lesions, which were all small nodular ground glass opacities.@*Conclusions@#The early chest CT images of children with 2019-nCoV infection are mostly small nodular ground glass opacities. The clinical symptoms of children with 2019-nCoV infection are nonspecific. Dynamic reexamination of chest CT and nucleic acid are important.read more
Citations
More filters
Journal ArticleDOI
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis.
Alfonso J. Rodriguez-Morales,Jaime A. Cardona-Ospina,Estefanía Gutiérrez-Ocampo,Rhuvi Villamizar-Peña,Yeimer Holguin-Rivera,Juan Pablo Escalera-Antezana,Lucia Elena Alvarado-Arnez,D. Katterine Bonilla-Aldana,Carlos Franco-Paredes,Andrés F. Henao-Martínez,Alberto Paniz-Mondolfi,Guillermo J. Lagos-Grisales,Eduardo Ramírez-Vallejo,José Antonio Suárez,Lysien I. Zambrano,Wilmer E. Villamil-Gómez,Graciela J. Balbin-Ramon,Ali A. Rabaan,Harapan Harapan,Kuldeep Dhama,Hiroshi Nishiura,Hiromitsu Kataoka,Tauseef Ahmad,Ranjit Sah +23 more
TL;DR: A systematic literature review with meta-analysis was performed using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases, finding that this virus brings a huge burden to healthcare facilities, especially in patients with comorbidities.
Journal ArticleDOI
Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.
TL;DR: The large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections.
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review.
Riccardo Castagnoli,Martina Votto,Amelia Licari,Ilaria Brambilla,Raffaele Bruno,Stefano Perlini,Francesca Rovida,Fausto Baldanti,Gian Luigi Marseglia +8 more
TL;DR: This is the first systematic review that assesses and summarizes clinical features and management of children with SARS-CoV-2 infection and concludes that Bronchial thickening and ground-glass opacities were the main radiologic features in asymptomatic patients.
Journal ArticleDOI
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children.
Petra Zimmermann,Nigel Curtis +1 more
TL;DR: Preliminary evidence suggests children are just as likely as adults to become infected with SARS-CoV-2 but are less likely to be symptomatic or develop severe symptoms, but the importance of children in transmitting the virus remains uncertain.
Journal ArticleDOI
Antibody tests for identification of current and past infection with SARS‐CoV‐2
Jonathan J Deeks,Jonathan J Deeks,Jacqueline Dinnes,Jacqueline Dinnes,Yemisi Takwoingi,Yemisi Takwoingi,Clare Davenport,Clare Davenport,René Spijker,René Spijker,Sian Taylor-Phillips,Sian Taylor-Phillips,Ada Adriano,Sophie Beese,Janine Dretzke,Lavinia Ferrante di Ruffano,Isobel Marion Harris,Malcolm J Price,Malcolm J Price,Sabine Dittrich,Devy Emperador,Lotty Hooft,Mariska M.G. Leeflang,Ann Van den Bruel +23 more
TL;DR: To assess the diagnostic accuracy of antibody tests to determine if a person presenting in the community or in primary or secondary care has SARS-CoV-2 infection, or has previously had SARS, and the accuracy of antibodies for use in seroprevalence surveys is assessed.
References
More filters
Journal ArticleDOI
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis.
Alfonso J. Rodriguez-Morales,Jaime A. Cardona-Ospina,Estefanía Gutiérrez-Ocampo,Rhuvi Villamizar-Peña,Yeimer Holguin-Rivera,Juan Pablo Escalera-Antezana,Lucia Elena Alvarado-Arnez,D. Katterine Bonilla-Aldana,Carlos Franco-Paredes,Andrés F. Henao-Martínez,Alberto Paniz-Mondolfi,Guillermo J. Lagos-Grisales,Eduardo Ramírez-Vallejo,José Antonio Suárez,Lysien I. Zambrano,Wilmer E. Villamil-Gómez,Graciela J. Balbin-Ramon,Ali A. Rabaan,Harapan Harapan,Kuldeep Dhama,Hiroshi Nishiura,Hiromitsu Kataoka,Tauseef Ahmad,Ranjit Sah +23 more
TL;DR: A systematic literature review with meta-analysis was performed using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases, finding that this virus brings a huge burden to healthcare facilities, especially in patients with comorbidities.
Journal ArticleDOI
Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.
TL;DR: The large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections.
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review.
Riccardo Castagnoli,Martina Votto,Amelia Licari,Ilaria Brambilla,Raffaele Bruno,Stefano Perlini,Francesca Rovida,Fausto Baldanti,Gian Luigi Marseglia +8 more
TL;DR: This is the first systematic review that assesses and summarizes clinical features and management of children with SARS-CoV-2 infection and concludes that Bronchial thickening and ground-glass opacities were the main radiologic features in asymptomatic patients.
Journal ArticleDOI
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children.
Petra Zimmermann,Nigel Curtis +1 more
TL;DR: Preliminary evidence suggests children are just as likely as adults to become infected with SARS-CoV-2 but are less likely to be symptomatic or develop severe symptoms, but the importance of children in transmitting the virus remains uncertain.
Journal ArticleDOI
Antibody tests for identification of current and past infection with SARS‐CoV‐2
Jonathan J Deeks,Jonathan J Deeks,Jacqueline Dinnes,Jacqueline Dinnes,Yemisi Takwoingi,Yemisi Takwoingi,Clare Davenport,Clare Davenport,René Spijker,René Spijker,Sian Taylor-Phillips,Sian Taylor-Phillips,Ada Adriano,Sophie Beese,Janine Dretzke,Lavinia Ferrante di Ruffano,Isobel Marion Harris,Malcolm J Price,Malcolm J Price,Sabine Dittrich,Devy Emperador,Lotty Hooft,Mariska M.G. Leeflang,Ann Van den Bruel +23 more
TL;DR: To assess the diagnostic accuracy of antibody tests to determine if a person presenting in the community or in primary or secondary care has SARS-CoV-2 infection, or has previously had SARS, and the accuracy of antibodies for use in seroprevalence surveys is assessed.