Patent
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
TLDR
In this paper, a microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations, using photolithographic procedures and chemical wet etching.Abstract:
A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.read more
Citations
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PatentDOI
Microfluidic large scale integration
TL;DR: The fluidic multiplexor as discussed by the authors is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs.
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High throughput screening assay systems in microscale fluidic devices
TL;DR: In this paper, the authors present novel microfluidic devices and methods that are useful for performing high-throughput screening assays for a variety of chemical and biochemical systems.
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Methods and apparatus for measuring analytes using large scale fet arrays
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Methods and apparatuses for analyzing polynucleotide sequences
TL;DR: In this article, a high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention of the algorithm.
References
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Journal ArticleDOI
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
TL;DR: In this article, the authors demonstrated a miniaturized system for sample handling and separation using electrophoresis-based separations of amino acids with up to 75,000 theoretical plates in about 15 seconds.
Journal ArticleDOI
Capillary electrophoresis and sample injection systems integrated on a planar glass chip
TL;DR: In this article, a complex manifold of capillary channels has been fabricated in a planar glass substrate and the separation of a mixture of fluorescein and calcein within the channels was achieved using electrophoresis.
Journal ArticleDOI
Planar chips technology for miniaturization and integration of separation techniques into monitoring systems. Capillary electrophoresis on a chip
Andreas Manz,D.J. Harrison,Elisabeth Verpoorte,James C. Fettinger,Aran Paulus,H. Lüdi,H.M. Widmer +6 more
TL;DR: In this paper, a chip-like structure for capillary electrophoresis is presented, which is based on the photolithographic technique for structures in the micrometer range.
PatentDOI
Active programmable electronic devices for molecular biological analysis and diagnostics
Michael J. Heller,Eugene Tu +1 more
TL;DR: A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats.
Journal ArticleDOI
Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices
TL;DR: In this paper, a glass microchip column was fabricated for free-solution electrophoresis and two methods of sample introduction were evaluated employing a cross-type channel geometry.