Journal ArticleDOI
Assessment of the Acute Toxicity and Analgesic Activity of Ethyl-6-Amino-4-Aryl-5-Cyano-2,4-Dihydropyrano-2,3-C]-Pyrazole-3-Carboxylates
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TLDR
The acute toxicity and analgesic activity of compounds of the ethyl-6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate series were investigated in this article.Abstract:
The acute toxicity and analgesic activity of compounds of the ethyl-6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate series were investigated. Study compounds were found to be essentially nontoxic and to have analgesic activity.read more
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Transition Metal‐free C‐H Sulfonylation and Pyrazole Annulation Cascade for the Synthesis of 4‐Sulfonyl Pyrazoles
TL;DR: In this paper, the synthesis of 4-sulfonyl pyrazoles via the reactions of readily available N,Ndimethyl enaminones and sulfonyl hydrazines has been developed via the catalysis of molecular iodine in the presence of TBHP and NaHCO3 at room temperature.
Design, Synthesis, and Biological Evaluation of Densely Substituted Dihydropyrano[2,3-c]pyrazoles via a Taurine-Catalyzed Green Multicomponent Approach.
Ghanshyam Mali,Badrodin Ayyub Shaikh,Shivani Garg,Akhilesh Kumar,Sudipta Bhattacharyya,Rohan D. Erande,Asha V. Chate +6 more
TL;DR: An efficient taurine-catalyzed green multicomponent approach has been described for the first time to synthesize densely substituted therapeutic core dihydropyrano[2,3-c]pyrazoles.
Journal ArticleDOI
Synthesis, Intramolecular Cyclization, and Analgesic Activity of Substituted 2-[2-(Furancarbonyl)hydrazinylydene]-4-oxobutanoic Acids
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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
Jia-Lun Wang,Dongxiang Liu,ZhiJia Zhang,Simei Shan,Xiaobing Han,Srinivasa M. Srinivasula,Carlo M. Croce,Emad S. Alnemri,Ziwei Huang +8 more
TL;DR: The discovery of HA14-1, a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket, provides a chemical probe to study B cl-2-regulated apoptotic pathways in vivo and could lead to the development of new therapeutic agents.
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Synthesis and biological activity of some pyrazole derivatives
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Multicomponent Reactions of Carbonyl Compounds and Derivatives of Cyanoacetic Acid : Synthesis of Carbo-and Heterocycles
TL;DR: A review of multicomponent reactions of carbonyl compounds with derivatives of cyanoacetic acid can be found in this paper, where the authors compare their results with other well-known multicomponents reactions.
Journal ArticleDOI
One pot four-component reaction for the efficient synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-3′-carboxylate derivatives
TL;DR: In this paper, a novel one pot protocol was developed to synthesize various spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-3′-carboxylate derivatives from the four-component reaction of isatin, malononitrile, hydrazine derivatives and dialkyl acetylenedicarboxylates.