Open AccessJournal Article
Assigning a probability for paternity in apparent cases of mutation
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TLDR
This paper deals with the quantification of this error by producing, under certain assumptions, the probability for paternity by means of a new direct estimator of the mutation rate.Abstract:
Any direct estimator of mutation in a human population is subject to error due to nonpaternity. This paper deals with the quantification of this error by producing, under certain assumptions, the probability for paternity. In addition, a new direct estimator of the mutation rate is introduced.read more
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Journal ArticleDOI
Relative mutation rates at di-, tri-, and tetranucleotide microsatellite loci
TL;DR: Applying ANOVA to the distributions of the allele sizes at microsatellite loci from a set of populations, grouped by repeat motif types, provides an estimate of motif-type-specific mutation rates up to a multiplicative constant, indicating that the earlier suggestion of higher mutation rates of tetranucleotides in comparison with the din nucleotides may stem from a nonrandom sampling of tetanucleotide loci in direct mutation assays.
Journal ArticleDOI
Estimation of nonpaternity in the Mexican population of Nuevo Leon: a validation study with blood group markers.
Ricardo M. Cerda-Flores,Sara A. Barton,Luisa F. Marty-Gonzalez,Fernando Rivas,Ranajit Chakraborty +4 more
TL;DR: It is concluded that even though DNA markers are more informative, the probabilistic approach developed here would still be needed to estimate the true rate of nonpaternity in a population or to evaluate the precision of detecting true fathers.
Journal ArticleDOI
Paternity exclusion by DNA markers: effects of paternal mutations.
TL;DR: The approach places a reduced weight on the combined exclusion probability, and the probability of exclusion based on combined tests on STR and VNTR loci is sufficiently large to resolve most paternity dispute cases in general populations.
Journal Article
The use of restriction fragment length polymorphisms in paternity analysis.
Peter E. Smouse,R Chakraborty +1 more
TL;DR: With current technology, RFLP analysis is more expensive for the same level of genetic resolution than is the standard battery, but gradual replacement of the latter can be anticipated as economies of scale reduce the cost of the DNA technology.