Journal ArticleDOI
Assignment of quaternary carbons via two-bond heteronuclear selective NOE difference, a useful structure elucidation aid
TLDR
In this paper, very low power irradiation of suitable narrow peaks in the proton frequency range generated NOE enhancement in neighbouring quaternary carbons, positioned two bonds from the irradiated protons.Abstract:
Very low power irradiation of suitable narrow peaks in the proton frequency range generated NOE enhancement in neighbouring quaternary carbons, positioned two bonds from the irradiated protons. Subsequent FID acquisition under normal broad band decoupling yielded the NOE-containing FID, which, after subtraction of the unperturbed broad band decoupled FID (devoid of NOE), gave the final NOE difference FID to which only the carbons undergoing NOE enhancement had contributed. Fourier transformation of the latter gave the NOE difference spectrum, usually a one- or two-peak spectrum. This technique proved particularly useful for polysubstituted aromatic rings.read more
Citations
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Journal ArticleDOI
Cyclometalated Complexes of Platinum and Palladium with N-(4-Chlorophenyl)-α-benzoylbenzylideneamine. in Vitro Cytostatic Activity, DNA Modification, and Interstrand Cross-Link Studies
Carmen Navarro-Ranninger,Isabel López-Solera,Víctor M. González,José M. Pérez,Amparo Alvarez-Valdés,Avelino Martín,Paul R. Raithby,José R. Masaguer,Carlos Alonso +8 more
TL;DR: In this article, the synthesis and structural IR and 1H and 13C NMR characterization of four platinum-II and palladium-II cyclometalated complexes of the formula [Pd(4-ClC6H4NC(COC6H5)C 6H4)X]2 was reported.
Journal ArticleDOI
Theoretical and practical aspects of one- and two-dimensional heteronuclear overhauser experiments and selective 13C T1-determinations of heteronuclear distances
Katalin E. Kövér,Gyula Batta +1 more
Journal ArticleDOI
Preparation and characterization of platinum(II) and (IV) complexes of 1,3-diaminepropane and 1,4-diaminebutane: circumvention of cisplatin resistance and DNA interstrand cross-link formation in CH1cisR ovarian tumor cells.
Amparo Alvarez-Valdés,José M. Pérez,Isabel López-Solera,R. Lannegrand,José Manuel Continente,Pilar Amo-Ochoa,María José Camazón,Xavier Solans,Mercè Font-Bardia,Carmen Navarro-Ranninger +9 more
TL;DR: In contrast with carboplatin (cis-diammine-1,1-cyclobutane dicarboxilatoplatinum(II)), compounds 1'a and 1'b, which also contain the CBDCA ligand, are able to circumvent cisplatin (diamminedichloropl platinum(II) resistance in several tumor cells.
Book ChapterDOI
Carbon-13 NMR Spectra of Sesquiterpene Lactones
M. Buděšínský,D. Šaman +1 more
TL;DR: In this article, the carbon-13 NMR data of sesquiterpene lactones were used for structure classification and methods of structure determination, and the most important methods discussed were: mass spectra, infrared, ultraviolet, NMR and X-ray.
Journal ArticleDOI
Regioselective nucleophilic attack on N-BOC-pyroglutamate ethyl ester
TL;DR: N-BOC ethyl pyroglutamate undergoes regioselective ring opening with different nucleophiles without racemization at the chiral centre as discussed by the authors.
References
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Journal ArticleDOI
Application of selective 13C{1H} nuclear overhauser effects with low-power 1H irradiation in carbon-13 NMR spectroscopy
Jun Uzawa,Setsuo Takeuchi +1 more
TL;DR: In this paper, the feasibility of the application of selective 13C{1H} nuclear Overhauser effect (NOE) measurements to organic structural analysis in 13C NMR spectroscopy has been investigated at 25 MHz using citraconic anhydride and the methyl ester of pentalenolactone as model compounds.
Journal ArticleDOI
Nitrophenyl ethers as possible photoaffinity labels. The nucleophilic aromatic photosubstitution revisited.
TL;DR: The photoreactions of nitrophenyl ethers with simple primary and secondary amines show a remarkable nucleophile influence on the reaction orientation as discussed by the authors, indicating a change from charge controlled to frontier orbital controlled reactions moving from smaller to larger amines.
Journal ArticleDOI
Structure and biosynthesis of setomimycin, a novel 9,9'-bianthryl antibiotic
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