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BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea; NSC-409962) in the treatment of malignant brain tumor--a preliminary report.
Walker,Hurwitz Bs +1 more
- Vol. 54, Iss: 4, pp 263
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The article was published on 1970-08-01 and is currently open access. It has received 86 citations till now. The article focuses on the topics: Nitrosourea.read more
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N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain.
Tsuyoshi Yamaguchi,Hiroyuki Kanemitsu,Satoshi Yamamoto,Masahiko Komatsu,Hiroyuki Uemura,Kazutoshi Tamura,Tomoyuki Shirai +6 more
TL;DR: It is suggested that BCNU induces p53-dependent apoptosis and reduces proliferative activity, resulting in reduction of the weight of the telencephalon and the thickness of the Telencephalic wall in the fetal brain.
Journal ArticleDOI
Chemosensitivity testing of human gliomas using a fluorescent microcarrier technique.
TL;DR: The use of the microcarrier technique allows for the direct cellular measurement of fluorescence without the need of extensive extraction procedures and the fluorescent assay is a sensitive, rapid and an effective way to screen for potential antiproliferative compounds.
Journal ArticleDOI
Combined chemotherapy with VM 26 and BCNU for recurrent malignant gliomas after operation and irradiation
TL;DR: In this paper, the preliminary results of a combined chemotherapy trial with VM 26 and BCNU for recurrent malignant gliomas are presented, and four patients out of seven responded favourably to this treatment.
Medulloblastoma in children
TL;DR: The findings in this study suggest that the primary treatment of medulloblastoma should be extended to include chemotherapy and optimum radiation therapy, since once recurrent disease develops retreatment is essentially palliative and a fatal outcome is virtually certain.