K
Kendall A. Smith
Researcher at Cornell University
Publications - 199
Citations - 28718
Kendall A. Smith is an academic researcher from Cornell University. The author has contributed to research in topics: Interleukin 2 & T cell. The author has an hindex of 71, co-authored 198 publications receiving 27972 citations. Previous affiliations of Kendall A. Smith include University of Würzburg & Boston Medical Center.
Papers
More filters
Journal Article
T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity
TL;DR: This highly reproducible, quantitative assay for T cell growth factor (TCGF), based upon the tritiated-thymidine incorporation of continuous murine tumor-specific cytotoxic T cell lines (CTLL), has revealed that T lymphocytes are required for its production.
Journal ArticleDOI
Interleukin-2: inception, impact, and implications.
TL;DR: Because T cell clonal proliferation after antigen challenge is obligatory for immune responsiveness and immune memory, the IL-2-T cell system has opened the way to a molecular understanding of phenomena that are fundamental to biology, immunology, and medicine.
Journal ArticleDOI
Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
Diana Finzi,Joel N. Blankson,Janet M. Siliciano,Joseph B. Margolick,Karen Chadwick,Theodore C. Pierson,Kendall A. Smith,Julianna Lisziewicz,Franco Lori,Charles Flexner,Thomas C. Quinn,Richard E. Chaisson,Eric S. Rosenberg,Bruce D. Walker,Stephen J. Gange,Joel E. Gallant,Robert F. Siliciano +16 more
TL;DR: The mean half-life of the latent reservoir was very long (43.9 months) and the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable as mentioned in this paper.
Journal ArticleDOI
Long term culture of tumour-specific cytotoxic T cells.
Steven Gillis,Kendall A. Smith +1 more
TL;DR: An adaptation of this method which allows the long term culture of antigen-selected cytotoxic T cells which continue to demonstrate high levels of syngeneic tumour-specific cytotoxicity after more than 4 months in culture is described.
Journal ArticleDOI
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.
TL;DR: Thalidomide inhibition of lipopolysaccharide-induced tumor necrosis factor alpha production is examined and it is found that the drug enhances the degradation of TNF-alpha mRNA, providing an explanation for the synergistic effects of these drugs.