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BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea; NSC-409962) in the treatment of malignant brain tumor--a preliminary report.
Walker,Hurwitz Bs +1 more
- Vol. 54, Iss: 4, pp 263
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The article was published on 1970-08-01 and is currently open access. It has received 86 citations till now. The article focuses on the topics: Nitrosourea.read more
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Interaction of 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) with Nucleic Acids and Proteins in Vivo and in Vitro
TL;DR: The possibility that the carcinostatic activity of this drug reflects a dual capacity, namely, modification of cellular proteins via cyclohexylcarbamoylation and of nucleic acids via alkylation, is discussed.
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The basis for current treatment recommendations for malignant gliomas.
TL;DR: Only through better understanding of the biology of these tumors, more effective therapies, and the implementation of better clinical trial design can the authors hope to make significant progress in the treatment of malignant gliomas.
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Clinical comparison of the nitrosoureas.
TL;DR: The nitrosourea group of antitumor agents was developed by the Division of Cancer Treatment of the National Cancer Institute and has undergone extensive clinical trials, and two of them will soon become commercially available.
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Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
TL;DR: In this article, the authors investigated the effect of adding temozolomide to O(6)-alkylguanine-DNA alkyltransferase (AGT) for the treatment of colorectal cancer.
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Antineoplastic agents and the liver
TL;DR: This review is to assess what is currently known of the interrelation between some of the more commonly used or a few of themore recently acquired chemotherapeutic drugs and the liver and propose a classification of the discussed agents in reference to hepatic involvement.