Patent
Benzoxazole kinase inhibitors and methods of use
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TLDR
In this paper, chemical entities or compounds and pharmaceutical compositions thereof are provided that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases.Abstract:
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.read more
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Patent
Heterocyclic compounds and uses thereof
Alfredo C. Castro,Catherine A. Evans,Somarajannair Janardanannair,Andre Lescarbeau,Tao Liu,Daniel A. Snyder,Martin R. Tremblay,Pingda Ren,Yi Liu,Liansheng Li,Katrina Chan +10 more
TL;DR: In this article, compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activation, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activations are described.
Patent
Certain chemical entities, compositions and methods
TL;DR: In this paper, chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 Kinase activity are described.
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Treatment of cancer using chimeric antigen receptor
TL;DR: In this paper, the authors present compositions and methods for treating diseases associated with the expression of cancer-associated antigens described herein, including methods of administering genetically modified T cells that express a CAR comprising an antigen binding domain that binds to a cancerassociated antigen described herein.
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Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
Michael C. Milone,Enxiu Wang +1 more
TL;DR: In this paper, the authors provide compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy using a type of chimeric antigen receptor (CAR) wherein the CAR is termed a "NKR-CAR" which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells.
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Heterocyclic kinase inhibitors
TL;DR: In this paper, the authors provide heterocyclic compounds for use as P13 kinase inhibitors and in other applications, as well as pharmaceutical compositions and methods of treatments of diseases and conditions associated with P 13 kinase activity.
References
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Journal ArticleDOI
Report of the expert committee on the diagnosis and classification of diabetes mellitus
James R. Gavin,K. G M M Alberti,Mayer B. Davidson,Ralph A. DeFronzo,Allan Drash,Steven G. Gabbe,Saul M. Genuth,Maureen I. Harris,Richard Kahn,Harry Keen,William C. Knowler,Harold E. Lebovitz,Noel K. Maclaren,Jerry P. Palmer,Philip Raskin,Robert A. Rizza,Michael P. Stern +16 more
TL;DR: It was deemed essential to develop an appropriate, uniform terminology and a functional, working classification of diabetes that reflects the current knowledge about the disease.
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Patent
Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
TL;DR: An expandable intraluminal vascular graft is expanded within a blood vessel by an angioplasty balloon associated with a catheter to dilate and expand the lumen of a vessel.
Book
Design of prodrugs
TL;DR: The design of prodrugs: Bioreversible derivatives for various functional groups and chemical entities based on enzyme-substrate specificity and their applications, as well as pharmacokinetic aspects, are presented.
Journal ArticleDOI
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
Thomas U. Mayer,Tarun M. Kapoor,Stephen J. Haggarty,Stephen J. Haggarty,Randall W. King,Stuart L. Schreiber,Stuart L. Schreiber,Timothy J. Mitchison +7 more
TL;DR: In vitro, monastrol specifically inhibited the motility of the mitotic kinesin Eg5, a motor protein required for spindle bipolarity, and will therefore be a particularly useful tool for studying mitotic mechanisms.