Journal ArticleDOI
Biological inactivation of progesterone by interaction with corticosteroid-binding globulin and with albumin.
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Results seem to show that the biological activity of progesterone is suppressed by complex formation with CBG or with serum albumin, as in the case of the ovariectomized mouse.Abstract:
Addition of a rat CBG preparation to a progesterone solution abolished the effect of the hormone on the ligated uterus of the ovariectomized mouse. Inactivation was also observed when rat serum albumin was used as the progesterone-binding protein. These results seem to show that the biological activity of progesterone is suppressed by complex formation with CBG or with serum albumin. (Endocrinology 85: 778, 1969)read more
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Corticosterone-binding proteins and behavioral effects of high plasma levels of corticosterone during the breeding period in the pied flycatcher.
TL;DR: The results show that an elevation of plasma levels of corticosterone in adult pied flycatchers during the nestling period affects parental as well as territorial behavior.
Journal ArticleDOI
Physiologic properties of steroid hormone-binding proteins in avian blood
TL;DR: Data suggest that the high-affinity binding protein in avian blood has physiologic properties similar to mammalian corticosteroid-binding globulin (CBP).
References
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Journal ArticleDOI
Established eurythermic line of fish cells in vitro.
Ken Wolf,M. C. Quimby +1 more
TL;DR: An established line of fish cells has been propagated in vitro for 21 months and 48 subcultivations and important characteristics of the cells are described.
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Transcortin: a corticosteroid-binding protein of plasma. X. Cortisol and progesterone interplay and unbound levels of these steroids in pregnancy.
TL;DR: The computed value for the association constant of the cortisol-transcortin complex in pregnancy plasma is about 12 μm−1 and that of the progesteronetranscortIn complex is about twice this value.
Journal ArticleDOI
Inactivity in vivo of transcortin-bound cortisol.
TL;DR: By means of a liver glycogen maintenance assay for corticosteroids, it was shown that transcortin-bound cortisol is biologically inactive.
Journal ArticleDOI
Corticosteroid-binding globulin in the rat: studies on the sex difference.
Richard R. Gala,Ulrich Westphal +1 more
TL;DR: The data suggested that testosterone suppresses CBG activity, and progesterone administration increased the binding activity of intact male and female animals.
Journal ArticleDOI
Δ4-3-KETOPREGNENE-20α-OL AND Δ4-3-KETOPREGNENE-20β-OL, TWO NATURALLY OCCURRING METABOLITES OF PROGESTERONE. ISOLATION, IDENTIFICATION, BIOLOGIC ACTIVITY AND CONCENTRATION IN HUMAN TISSUES
TL;DR: The relative concentrations of both compounds in the placenta in the second to the tenth month of pregnancy and in the ovary during the menstrual cycle and pregnancy have been quantitatively determined and compared to progesterone levels in these tissues.