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Biomaterials by design: Harnessing data for future development

TLDR
In this paper, the authors discuss the recent work on the use of machine learning in the discovery and design of biomaterials, including new polymeric, metallic, ceramics, and nanomaterials.
Abstract
Biomaterials is an interdisciplinary field of research to achieve desired biological responses from new materials, regardless of material type. There have been many exciting innovations in this discipline, but commercialization suffers from a lengthy discovery to product pipeline, with many failures along the way. Success can be greatly accelerated by harnessing machine learning techniques to comb through large amounts of data. There are many potential benefits of moving from an unstructured empirical approach to a development strategy that is entrenched in data. Here, we discuss the recent work on the use of machine learning in the discovery and design of biomaterials, including new polymeric, metallic, ceramics, and nanomaterials, and how machine learning can interface with emerging use cases of 3D printing. We discuss the steps for closer integration of machine learning to make this exciting possibility a reality.

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Citations
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Emerging early diagnostic methods for acute kidney injury

TL;DR: This review comprehensively summarizes the application of machine learning in AKI prediction algorithms and specific scenarios, and introduces the key role of early biomarkers in the progress of AKI, and comprehensively summarize theApplication of emerging detection technologies for early AKI.
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A User’s Guide to Machine Learning for Polymeric Biomaterials

TL;DR: The Google Colab notebook as discussed by the authors provides a step-by-step guide to the use of machine learning in biomaterials development, using data from a real biomaterial design challenge based on group's research.
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Potential of Recycled Silicon and Silicon-Based Thermoelectrics for Power Generation

TL;DR: In this paper , the authors summarize the usage of high-temperature thermoelectric generators (TEGs) in applications such as commercial aviation and space voyages, which can be used to guide sustainable recycling of e-waste into TEGs for power harvesting.
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Bottom-up design of hydrogels for programmable drug release.

TL;DR: In this paper , the authors present a review of physical models of hydrogel release and discuss the interesting potential and challenges for programming release, and potential implications with the advent of machine learning.
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Machine Learning in Tissue Engineering

TL;DR: A recent review as discussed by the authors highlights the novel methodologies, emerging strategies, and areas of potential growth within this rapidly evolving area of research, including machine-optimized biomaterial design, predictive modeling of scaffold fabrication, and spatiotemporal analysis of cell and tissue systems.
References
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Journal ArticleDOI

An optimization method for multi-objective and multi-factor designing of a ceramic slurry: Combining orthogonal experimental design with artificial neural networks

TL;DR: In this article, orthogonal experiment design (OED) and back propagation artificial neural networks (BP ANNs) were combined to solve multiobjective and multi-factor problems caused by the preparation of alumina slurry.
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Machine learning metrology of cell confinement in melt electrowritten three-dimensional biomaterial substrates.

TL;DR: The technology platform established here constitutes a significant step towards the development of integrated additive manufacturing—metrology platforms for a wide range of applications including fundamental mechanobiology studies and 3D bioprinting of tissue constructs to yield specific biological designs qualified at the single-cell level.
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An online tool for predicting fatigue strength of steel alloys based on ensemble data mining

TL;DR: In this article, the authors describe the development and deployment of data-driven ensemble predictive models for fatigue strength of a given steel alloy represented by its composition and processing information, and the developed predictive models are deployed in a user-friendly online web-tool available at http://info.eecs.northwestern.edu/steelFatigueStrengthPredictor.
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Neural network applications in determining the fatigue crack opening load

TL;DR: In this article, a neural network approach is developed to determine the crack opening load from differential displacement signal curves, which is applied in practical to constant amplitude loading tests and is found to provide good results.
Trending Questions (1)
What are the machine learning tools can be used for biomaterial design and development?

Machine learning techniques can be used for biomaterial design and development, as discussed in the paper "Biomaterials by design: Harnessing data for future development."