Journal ArticleDOI
Body fat distribution and C-reactive protein--a principal component analysis.
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A central pattern of fat distribution is directly associated with hs-CRP levels in men, while a high proportion of peripheral subcutaneous fat seems to be inversely associated with the protein, but only in women.Abstract:
Background and Aims To assess, using principal component analysis, the independent associations of general, central and peripheral subcutaneous fat with high-sensitivity C-reactive protein (hs-CRP), in men and women from the general population. Methods and results We studied 833 women and 486 men, randomly selected from the non-institutionalized population of Porto, Portugal, with information on hs-CRP (≤10mg/l) and anthropometrics (1999–2003). Body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and a skinfold composite index to estimate the proportion of arm subcutaneous fat (PSFA), were ascertained by trained personnel. Beta regression coefficients were obtained from generalized linear models with adjustment for the main confounders. Direct associations were found between BMI, WC, WHR and hs-CRP. PSFA was inversely associated with hs-CRP in women ( β ˆ =−0.080, p -trend=0.010). Since the anthropometric measures were strongly correlated, we used principal component analysis to identify new independent anthropometric factors. The first one, representing a generalized fat distribution (high BMI and WC), was directly associated with hs-CRP ( β ˆ =0.226, p -trend β ˆ =0.138, p -trend=0.002 in men). The second factor, characterized by a high PSFA, showed an inverse association with hs-CRP in women ( β ˆ =−0.071, p -trend=0.048). The third factor, representing a central pattern of fat distribution (low BMI, but high WC and high WHR), was directly associated with hs-CRP in men ( β ˆ =0.090, p -trend=0.005). Conclusion A central pattern of fat distribution is directly associated with hs-CRP levels in men, while a high proportion of peripheral subcutaneous fat seems to be inversely associated with hs-CRP, but only in women.read more
Citations
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High prevalence of overweight and obesity in adults with Crohn's disease: Associations with disease and lifestyle factors
TL;DR: A novel association between higher BMI and higher CRP is identified, a marker linked both with obesity in the general population and with CD, suggesting stable disease, as well as older age and lower physical activity.
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Prevalence and incidence of cognitive impairment in an elder Portuguese population (65-85 years old).
TL;DR: The prevalence of cognitive impairment in Portugal is within the estimated interval for the European population, and the incidence is lower than for the majority of the European countries.
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Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians.
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Central body fat changes in men affected by post-surgical hypogonadotropic hypogonadism undergoing testosterone replacement therapy are modulated by androgen receptor CAG polymorphism.
TL;DR: In male post-surgical hypogonadotropic hypogOnadism, shorter length of AR CAG repeat tract is independently associated with a more marked decrease of abdominal fat after TRT.
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Predictors of Serum Levels of High Sensitivity C-Reactive Protein and Systolic Blood Pressure in Overweight and Obese Nondiabetic Women in Tehran: A Cross-Sectional Study
Tirang R. Neyestani,Shabnam Salekzamani,Ali Kalayi,Hamid Alavi-Majd,Anahita Houshiarrad,Bahareh Nikooyeh,Nastaran Shariatzadeh +6 more
TL;DR: FM and WC were identified as the predictors of serum hsCRP levels and BMI as the predictor of SBP in the population of overweight/obese nondiabetic women in Tehran.
References
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Peter McCullagh,John A. Nelder +1 more
TL;DR: In this paper, a generalization of the analysis of variance is given for these models using log- likelihoods, illustrated by examples relating to four distributions; the Normal, Binomial (probit analysis, etc.), Poisson (contingency tables), and gamma (variance components).
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Peter McCullagh,John A. Nelder +1 more
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Generalized Linear Models
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Reproducibility and validity of a semiquantitative food frequency questionnaire
Walter C. Willett,Walter C. Willett,Laura Sampson,Meir J. Stampfer,Meir J. Stampfer,Bernard Rosner,Chris Bain,Jelia C. Witschi,Charles H. Hennekens,Frank E. Speizer +9 more
TL;DR: Data indicate that a simple self-administered dietary questionnaire can provide useful information about individual nutrient intakes over a one-year period.