(+)-Camphor-derived tri- and tetradentate amino alcohols; synthesis and application as ligands in the nickel catalyzed enantioselective conjugate addition of diethylzinc

TLDR: In this paper, the amino alcohols were employed as chiral ligands in the nickel catalyzed conjugate additions of diethylzinc to chalcone and cyclohexenone as model substrates.

Abstract: Several novel tri- and tetradentate amino alcohol ligands, all derived from (+)-camphor, have been synthesized by using specific N -alkylation procedures. The amino alcohols were employed as chiral ligands in the nickel catalyzed conjugate additions of diethylzinc to chalcone and cyclohexenone as model substrates. For the acyclic enone enantioselectivities up to 83% were achieved.

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University of Groningen
(+)-camphor-derived tri- and tetradentate amino alcohols; synthesis and application as
ligands in the nickel catalyzed enantioselective conjugate addition of diethylzinc
Vries, André H.M. de; Imbos, Rosalinde; Feringa, Bernard
Published in:
Tetrahedron-Asymmetry
DOI:
10.1016/S0957-4166(97)00145-6
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Publication date:
1997
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Vries, A. H. M. D., Imbos, R., & Feringa, B. (1997). (+)-camphor-derived tri- and tetradentate amino
alcohols; synthesis and application as ligands in the nickel catalyzed enantioselective conjugate addition of
diethylzinc.
Tetrahedron-Asymmetry
,
8
(9), 1467-1473. https://doi.org/10.1016/S0957-4166(97)00145-6
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