Journal ArticleDOI
Catalytic Enantioselective Conjugate Addition of Dialkylzincs to α,β‐Unsaturated Ketones Using Nickel Bromide ‐ N,N‐Dibutylnorephedrine.
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This article is published in ChemInform.The article was published on 1989-05-23. It has received 2 citations till now. The article focuses on the topics: Bromide & Conjugate.read more
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Phosphoramidites: marvellous ligands in catalytic asymmetric conjugate addition.
TL;DR: The breakthrough is presented using chiral phosphoramidite ligands for copper-catalyzed dialkylzinc additions for enantioselective carbon-carbon bond formation by 1,4-addition of organometallic reagents to enones.
Journal ArticleDOI
Phosphoramidites: Marvellous Ligands in Catalytic Asymmetric Conjugate Addition
TL;DR: In this article, the development of an efficient catalytic system for enantioselective carbon−carbon bond formation by 1,4-addition of organometallic reagents (organolithium, Grignard, and organozinc reagents) to enones is presented.
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Catalytic Enantioselective Conjugate Addition of Dialkylzincs to α,β-Unsaturated Ketones Using Nickel Bromide–N,N-Dibutylnorephedrine
TL;DR: Combination of nickel bromide and N,N-dibutylnorephedrine catalyzed the enantioselective conjugate addition of dialkylzincs to α, β-unsaturated ketones to afford optically active β-substituted ketones in up to ca. 50% enantiomeric excess.