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Journal ArticleDOI

Cerebral Dysfunction and Childhood Psychoses

I. Kolvin, +2 more
- 01 Apr 1971 - 
- Vol. 118, Iss: 545, pp 407-414
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TLDR
The present authors have used only age of onset and behavioural features as their ascertainment criteria it was a behavioural rather than an aetiological diagnosis.
Abstract
A series of recent papers (Creak, 1961, 1963; Rutter, 1966; Brown, 1963; Lotter, 1967; Schain and Yannet, 1960) have provided evidence of degrees of cerebral dysfunction in infantile autism (Kanner, 1943) and other infantile psychoses. They have demonstrated that groups of cases of infantile psychoses satisfying broadly similar diagnostic criteria have in their backgrounds a variable frequency of cerebral insult and abnormal discharge in the EEC The diagnostic criteria in such series are of crucial importance. Imprecision and vagueness hamper comparisons between series. In childhood psychoses some investigators have excluded those cases in which there was any history or clinical evidence of organic features in an attempt to obtain a ‘pure’ group. This technique, while valid in delineating a syndrome, is handicapping to subsequent etiological study. For these reasons the present authors have used only age of onset and behavioural features as their ascertainment criteria it was a behavioural rather than an aetiological diagnosis.

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Journal ArticleDOI

A Neurological Model for Childhood Autism

TL;DR: The behavioral and motor disturbances in childhood autism are analyzed to propose that the syndrome results from dysfunction in a system of bilateral neural structures that includes the ring of mesolimbic cortex located in the mesial frontal and temporal lobes, the neostriatum, and the anterior and medial nuclear groups of the thalamus.
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The influence of age and sex on the onset and early course of schizophrenia.

TL;DR: The early course of the disease was similar across age groups, except there was a longer period of negative symptoms before first admission in late-onset schizophrenia in women, and the few significant age differences in symptoms were presumably due to general age-dependent reaction patterns like anxiety and depression or the cognitive development of personality.
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Infantile Autism Reviewed: A Decade of Research

TL;DR: The overwhelming evidence suggests that te treatment of choice for maximal benefit to autistic children is a systematic, intrusive behavioral/educational approach, and the typical prognostic picture is poor in terms of achieving self-supportive adulthood.
Journal ArticleDOI

Infantile autism: A total population study of reduced optimality in the pre-, peri-, and neonatal period

TL;DR: Autistic children showed greatly increased scores for reduced optimality, especially with regard to prenatal factors, at odds with early reports that children with autism had not suffered potential brain injury.
Journal ArticleDOI

Factors related to outcome in autistic children

TL;DR: Speech and IQ together correlated more highly with outcome than did any other combination of variables and set of fits in adolescence in some autistic children confirms that evidence of neurological abnormalities increases with age.