Changes of myocardial enzyme activities in atrial fibrillation.
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Higher cholinesterase and lower succinyldehydrogenase activity has been found in atrial fibrillation than in sinus rhythm, and it is not possible to decide whether the changes in enzyme activities are the cause or the result of atrial Fibrillation.Abstract:
Cholinesterase and succinyldehydrogenase activity of surgically removed left atrial auricles from patients in atrial fibrillation and in sinus rhythm have been compared, using histochemical methods. Higher cholinesterase and lower succinyldehydrogenase activity has been found in atrial fibrillation than in sinus rhythm. The pulmonary capillary mean pressure of patients with atrial fibrillation and sinus rhythm have been also compared. There was no significant difference between the two groups. On the basis of the reported examinations, it is not possible to decide whether the changes in enzyme activities are the cause or the result of atrial fibrillation.read more
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Sinus bradycardia. Autonomic influences and clinical assessment.
TL;DR: It is suggested that the investigations presented are useful in the routine assessment of patients presenting with syncope and sinus bradycardia, and those patients with symptoms and poor autonomic responses may require pacing while those with physiological responses may need no treatment or may be helped by drugs.
References
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Action of acetylcholine on rabbit auricles in relation to acetylcholine synthesis.
Edith Bülbring,J. H. Burn +1 more
TL;DR: To test the hypothesis that acetylcholine is present in heart muscle playing an important part in the processes responsible for its spontaneous contractions, experiments have now been performed on isolated auricles allowed to beat for many hours until they stopped.
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Auricular Fibrillation Induced and Maintained in Animals by Acetylcholine or Vagal Stimulation
Ted A. Loomis,Stephen Krop +1 more
TL;DR: Animals pretreated with appropriate doses of anticholinesterase agents develop auricular flutter and fibrillation following injection of acetylcholine or vagal stimulation, and atropine in small doses reverts the fibrills to normal sinus rhythm.