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Chemistry and Toxicology of Pyrrolizidine Alkaloids
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The article was published on 1986-04-01 and is currently open access. It has received 625 citations till now. The article focuses on the topics: Pyrrolizidine & Pyrrolizidine alkaloid.read more
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Sequestration of defensive substances from plants by Lepidoptera.
TL;DR: The biochemical, physiological, and ecological characteristics of phytochemical-based defense systems that can shed light on the evolution of the widely developed sequestering lifestyles among the Lepidoptera are illustrated.
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Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms.
TL;DR: This review presents updated information on the metabolism, metabolizing enzymes, and the mechanisms by which pyrrolizidine alkaloids exert genotoxicity and tumorigenicity.
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Long-Term, Near-Total Liver Replacement by Transplantation of Isolated Hepatocytes in Rats Treated with Retrorsine
Ezio Laconi,Ran Oren,Deb K. Mukhopadhyay,Ethel Hurston,Sergio Laconi,Paolo Pani,Mariana D. Dabeva,David A. Shafritz +7 more
TL;DR: The extensive proliferation of transplanted cells in this setting of persistent inhibition of resident hepatocytes represents a new general model to study basic aspects of liver repopulation with potential applications in chronic liver disease and ex vivo gene therapy.
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The potential of alkaloids in drug discovery.
TL;DR: This article suggests why now, with the presently available technology, and the remaining biome available and reasonably accessible, is an opportune moment to consciously focus on the discovery of further alkaloids with pharmacophoric utility.
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Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis
Ruth A. Roberts,Patricia E. Ganey,Changqing Ju,Lisa M. Kamendulis,Ivan Rusyn,James E. Klaunig +5 more
TL;DR: The data presented in this symposium illustrate to the toxicologist the central role played by Kupffer cells in mediating hepatotoxicity.