J
James E. Klaunig
Researcher at Indiana University
Publications - 251
Citations - 16180
James E. Klaunig is an academic researcher from Indiana University. The author has contributed to research in topics: Oxidative stress & DNA damage. The author has an hindex of 56, co-authored 238 publications receiving 14808 citations. Previous affiliations of James E. Klaunig include Indiana University – Purdue University Indianapolis & University of North Carolina at Chapel Hill.
Papers
More filters
Journal ArticleDOI
Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea
TL;DR: An antioxidant fraction of Chinese green tea, containing several catechins, has been previously shown to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in mouse skin and was shown to have antioxidative activity toward hydrogen peroxide and the superoxide radical.
Journal ArticleDOI
The Role of Oxidative Stress in Carcinogenesis
TL;DR: This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species.
Journal ArticleDOI
Oxidative Stress and Oxidative Damage in Carcinogenesis
TL;DR: Evidence demonstrates an association between a number of single nucleotide polymorphisms in oxidative DNA repair genes and antioxidant genes with human cancer susceptibility and the resultant altered gene expression patterns evoked by ROS contribute to the carcinogenesis process.
Journal ArticleDOI
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J. Calabrese,Kenneth Bachmann,A. John Bailer,P. Michael Bolger,Jonathan Borak,Lu Cai,Nina Cedergreen,M. George Cherian,Chuang Chin Chiueh,Thomas W. Clarkson,Ralph R. Cook,David M. Diamond,David J. Doolittle,Michael A. Dorato,Stephen O. Duke,Ludwig E. Feinendegen,Donald E. Gardner,Ronald W. Hart,Kenneth L. Hastings,A. Wallace Hayes,George R. Hoffmann,John A. Ives,Zbigniew Jaworowski,Thomas E. Johnson,Wayne B. Jonas,Norbert E. Kaminski,John G. Keller,James E. Klaunig,Thomas B. Knudsen,Walter J. Kozumbo,Teresa Lettieri,Shu Zheng Liu,Andre Maisseu,Kenneth I. Maynard,Edward J. Masoro,Roger O. McClellan,Harihara M. Mehendale,Carmel Mothersill,David B. Newlin,Herbert N. Nigg,Frederick W. Oehme,Robert F. Phalen,Martin A. Philbert,Suresh I. S. Rattan,Jim E. Riviere,Joseph Rodricks,Robert M. Sapolsky,Bobby R. Scott,Colin Seymour,David A. Sinclair,Joan Smith-Sonneborn,Elizabeth T. Snow,Linda P. Spear,Donald E. Stevenson,Yolene Thomas,Maurice Tubiana,Gary M. Williams,Mark P. Mattson +57 more
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
Journal ArticleDOI
PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance
James E. Klaunig,Michael A. Babich,Karl Baetcke,Jon C. Cook,J. Chris Corton,Raymond M. David,John G. DeLuca,David Y. Lai,Richard H. McKee,Jeffrey M. Peters,Ruth A. Roberts,Penelope A. Fenner-Crisp +11 more
TL;DR: An in-depth analysis of the state of the science on several topics critical to evaluating the relationship between the MOA for PPARα agonists and the human relevance of related animal tumors produces a range of outcomes, depending partly on the quality and quantity of MOA data available from laboratory animals and related information from human data sources.