Journal ArticleDOI
Chemotaxis of polymorphonuclear leukocytes by protein A of the staphylococcus.
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TLDR
Protein A, a component of staphylococcal cell wall in the presence of fresh human serum is highly chemotactic in vitro for human polymorphonuclear leukocytes, and may be the result of activation ofChemotactic complement components generated by the reaction between protein A and nonimmune γ globulin.Abstract:
SummaryProtein A, a component of staphylococcal cell wall in the presence of fresh human serum is highly chemotactic in vitro for human polymorphonuclear leukocytes. Chemotaxis is dependent upon heat-labile factors, presumably complement within serum. Laudable pus in staphylococcal infection may, therefore, be the result of activation of chemotactic complement components generated by the reaction between protein A and nonimmune γ globulin.read more
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Book ChapterDOI
Protein A of Staphylococcus aureus and related immunoglobulin receptors produced by streptococci and pneumonococci
TL;DR: This chapter discusses the occurrence, properties, applications, biological activity, and potential significance of Ig receptors produced mainly by staphylococci and streptococci, more broadly classified more broadly as Ig receptors.
Journal ArticleDOI
Lymphocyte stimulation by protein A of Staphylococcus aureus.
TL;DR: Data are presented showing that SpA is a highly efficient mitogen for human peripheral B lymphocytes, with no detectable activity for T lymphocyte, in order to achieve optimal stimulating conditions SpA should be presented to the lymphocytes on an insoluble matrix.
Journal ArticleDOI
γ Interferon induced by S. aureus protein A augments natural killing and ADCC
TL;DR: It is demonstrated that SpA induces the production of γ interferon (IFN-γ) in nonadherent, T lymphocyte-depleted (E−), Fc receptor-bearing (FcR+) human peripheral blood lymphocytes, and the data suggest that IFn-γ is a potent stimulator of both NK and ADCC activity.
Journal ArticleDOI
Protein A from Staphylococcus aureus: the biological significance of its reaction with IgG.
Arne Forsgren,Kristina Nordström +1 more
TL;DR: Protein A from Staphylococcus aureus was brought to common attention in 1958 by Jensen and in a more extensive study in 1962, Lofkvist and Sjoquist *-c found that Jensen’s antigen A was a protein and similar results were also obtained by Grov and colleagues.
Journal ArticleDOI
Leukocyte Locomotion and Chemotaxis: Effects of Bacteria and Viruses
TL;DR: How studies of the effects of microorganisms on the locomotion of leukocytes in in vitro assay systems may help to understand the more complex interaction that takes place in the infected host is considered.
Related Papers (5)
Protein a from Staphylococcus Aureus: IX. Complement-fixing activity of Protein A-IgG complexes
J. Sjöquist,G. Stålenheim +1 more