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Chronic recurrent multifocal osteomyelitis in children
TLDR
It has been shown that histological examination alone does not allow the distinction of CRMO from acute or subacute bacterial osteomyelitis, therefore an extensive microbial workup of the tissue biopsy, including PCRtechniques, is essential in order to establish the diagnosis and decide as to the treatment.Abstract:
Chronic recurrent multifocal osteomyelitis (CRMO) in children is an inflammatory disorder. It affects mainly the metaphyses of the long bones, in addition to the spine, the pelvis and the shoulder girdle. However, bone lesions can occur at any site of the skeleton. Even though this disease has been recognized as a clinical entity for almost three decades now, its origin and pathogenesis are not entirely clear. No apparent infectious agents are detectable at the site of the bone lesion. No epidemiological data on incidence and prevalence have been published so far. However, incidence might be something around 1:1,000,000, thus reflecting the number of patients followed-up. Clinical diagnosis in an affected child can be difficult because the clinical picture and course of disease may vary significantly. It has been shown that histological examination alone does not allow the distinction of CRMO from acute or subacute bacterial osteomyelitis. Therefore an extensive microbial workup of the tissue biopsy, including PCRtechniques, is essential in order to establish the diagnosis and decide as to the treatment. Non steroid anti-inflammatory drugs (NSAID) are the treatment of choice. In case of frequent relapses oral steroid treatment, bisphosphonates and azulfidine have been used and are reported to be beneficial.read more
Citations
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Journal ArticleDOI
Chronic non-bacterial osteomyelitis in children
Hermann J. Girschick,P Raab,S Surbaum,A Trusen,S Kirschner,Peter M. Schneider,Thomas Papadopoulos,Hans Konrad Müller-Hermelink,P E Lipsky +8 more
TL;DR: CNO is a spectrum of inflammatory conditions, with CRMO being the most severe, but most children with CNO have a favourable outcome of the disease.
Journal ArticleDOI
Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO)
Paivi Miettunen,Xing-Chang Wei,Deepak Kaura,Walid Abou Reslan,Alberto Nettel Aguirre,James D. Kellner +5 more
TL;DR: Pamidronate resulted in resolution of pain and MRI documented inflammation in all patients and it is proposed that pamidronsate is an effective second-line therapy in persistent CRMO.
Journal ArticleDOI
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ten cases and review of the literature.
Benedetta C. Beretta-Piccoli,MJ Sauvain,Imre Gal,Andreas Schibler,Traudel Saurenmann,Helene Kressebuch,Mario G. Bianchetti +6 more
TL;DR: The synovitis, acne, pustulosis, hyperostosis, osteitis syndrome is pertinent even in paediatrics since skin involvement is frequent, and in adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome.
Journal ArticleDOI
Current Understanding of the Pathogenesis and Management of Chronic Recurrent Multifocal Osteomyelitis
Polly J. Ferguson,Monica Sandu +1 more
TL;DR: There is a strong association with inflammatory disorders of the skin and intestinal tract in affected individuals and their close relatives, suggesting a shared pathophysiology and supporting a genetic component to disease susceptibility.
Journal ArticleDOI
Chronic Recurrent Multifocal Osteomyelitis
TL;DR: Non-steroidal anti-inflammatory drugs cause relief of symptoms in the majority of cases and Bisphosphonates and TNF-α blockers are alternatives for patients who do not respond or who have spinal involvement.
References
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Journal Article
Pustulotic arthroosteitis and chronic recurrent multifocal osteomyelitis in children. Report of three cases.
J. P. Huaux,Walter Esselinckx,Jean-Jacques Rombouts,Baudouin Maldague,Jacques Malghem,Jean-Pierre Devogelaer,C Nagant de Deuxchaisnes +6 more
TL;DR: 3 children with pustulosis palmaris et plantaris associated with chronic recurrent (multifocal) osteomyelitis, located in the clavicle in 2 patients, and in the distal fibula as well as in several metatarsals in the third, represent the arthrosteitis and chronic recurrent multifocal osteomyelsitis syndrome associated with palmoplantar pustULosis.
Journal ArticleDOI
Psoriatic arthritis and synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome.
TL;DR: Some cases of psoriatic arthritis are associated with an inflammatory bone disease, frequently seen on the anterior chest wall, which is part of the newly described SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome.
Journal ArticleDOI
Inflammatory hyperostosis and sclerosis of the clavicle
Anne Grethe Jurik,B N Møller +1 more
TL;DR: Six cases with chronic inflammatory hyperostotic and sclerotic changes of the clavicle are reported, and four patients had involvement of other bones including the thoracic spine, the femur, the tibia and the sternal end of the other clavicles.
Journal ArticleDOI
Chronic recurrent multifocal osteomyelitis
TL;DR: The clinical, radiological and histopathological results of an analysis of 29 cases of the so-called "chronic recurrent multifocal osteomyelitis" (CRMO) are presented and correlated to current data from the literature.
Journal ArticleDOI
Primary chronic osteomyelitis.
L Jani,Wolfgang Remagen +1 more
TL;DR: It is suggested that the term “primary chronic osteomyelitis” should be used to distinguish the condition from acute and secondary osteomyalitis as well as from other diseases, such as bone tumours.