Journal ArticleDOI
Circadian rhythm of adrenal cortical activity in depression. II. A comparison of types in depression.
TLDR
Evidence is presented further substantiating the hypothesis that changes in the level and timing of adrenal cortical activity in depression represented a response of the pituitary adrenal axis of the depressed patient to the discomfort associated with the depression.Abstract:
IN a previous article,1this research group presented evidence which suggested an alteration in the circadian rhythm of adrenal cortical activity in depression. The data showed that there was not only an increase in the level of serum and urinary 17-hydroxycorticosteroids (17-OHCS) in depressed patients but that the timing of this increase was different in the depressed patients compared to controls. It was pointed out in this article that the alteration in the circadian rhythm of adrenal cortical activity paralleled the changes in mood commonly described in depression. It was suggested that these changes in the level and timing of adrenal cortical activity in depression represented a response of the pituitary adrenal axis of the depressed patient to the discomfort associated with the depression. This article will present evidence further substantiating that hypothesis by showing that the level of adrenal corticalread more
Citations
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Journal ArticleDOI
Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders
TL;DR: Evidence is presented supportive of the notion that the pathophysiology of the Affective disorders involves a disruption of circadian rhythms and that the primary locus of action of agents effective in the affective disorders is on the circadian rhythm system.
Journal ArticleDOI
Reduced Cortisol Latency in Depressive Illness
TL;DR: A reduced time between sleep onset and the nocturnal increase in cortisol secretion suggests a possible biologic correlate of a depressive illness that might be useful as an illness marker in depressed patients.
Journal ArticleDOI
Tryptophan metabolism in depression
G. Curzon,P. K. Bridges +1 more
TL;DR: There was no consistent temporal relationship between excretion of metabolites and severity of the depressive illness, and the possible significance of the findings in relation to defective tryptophan metabolism in the brain in endogenous depression is commented upon.
Journal ArticleDOI
Relationships between stress and brain 5-hydroxytryptamine and their possible significance in affective disorders.
TL;DR: In this article, the authors describe an animal model relevant to depressive illness, which was prompted by the hope of eventually developing an anthropomorphic model of animals relevant to human affective disorders.
References
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Journal ArticleDOI
The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma.
Robert H. Silber,Curt C. Porter +1 more
TL;DR: Nelson and Samuels improved the procedure, primarily by employing chromatographic separation and micro cuvettes, so that they were able to measure the concentration of hydrocortisone in human plasma.
Journal ArticleDOI
The Nosology of Depression: The Endogenous-Reactive Concept
Joe Mendels,Carl Cochrane +1 more
TL;DR: There is sufficient consensus to support the independence of the endogenous and reactive factors, but it is suggested that these factors may not represent two etiologically distinct types of depression.
Book ChapterDOI
Determination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma.
Robert H. Silber,Curt C. Porter +1 more
Journal ArticleDOI
Plasma Cortisol Levels in Depression
TL;DR: In a group of eight normal subjects, Perkoff changed the sleep rhythm to sleeping during the day, using darkened rooms, and found that the plasma cortisol level followed suit, rising sharply in the two-hour period before waking.