Journal ArticleDOI
Clinical experience with the amniotic fluid lecithin-sphingomyelin ratio. I. Antenatal prediction of pulmonary maturity.
TLDR
The association of an L/S ratio greater than 2.0 with a low incidence of RDS and virtual absence of HMD substantiates the value of this method as a predictor of fetal pulmonary maturity.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1973-02-15. It has received 125 citations till now. The article focuses on the topics: Lecithin–sphingomyelin ratio & Amniotic fluid.read more
Citations
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Journal ArticleDOI
Diabetic pregnancy and perinatal morbidity
John L. Kitzmiller,John P. Cloherty,M.Donna Younger,Ashraf Tabatabaii,Suzanne B. Rothchild,Ilene R. Sosenko,Michael F. Epstein,Shailini Singh,Raymond K. Neff +8 more
TL;DR: Pregnancy outcome was analyzed in 147 diabetic women, 71 per cent of whom were dependent on insulin for more than 10 years, and polyhydramnios was a frequent maternal complication and was associated with premature labor and neonatal death in two cases.
Journal ArticleDOI
Phosphatidylinositol and phosphatidylglycerol in amniotic fluid: indices of lung maturity.
Mikko Hallman,Mikko Hallman,Marie V. Kulovich,Marie V. Kulovich,Elsa Kirkpatrick,Elsa Kirkpatrick,Robert G. Sugarman,Robert G. Sugarman,Louis Gluck,Louis Gluck +9 more
TL;DR: Analysis of PI and PG in amniotic fluid as markers of surfactant seems to be of value as an additional index of prenatal evaluation of lung maturity and may be particularly useful when the specimen is contaminated with blood.
Journal ArticleDOI
The lung profile. I. Normal pregnancy.
TL;DR: The lung profile run by two-dimensional thin-layer chromatography is described, including the L/S ratio and the percentages of disaturated acetone precipitated lecithin, PI, and PG, and results show that the accuracy of this profile increases that of the mature L/ S ratio value even further.
Journal ArticleDOI
The interpretation and significance of the lecithin-sphingomyelin ratio in amniotic fluid.
Louis Gluck,Louis Gluck,Marie V. Kulovich,Marie V. Kulovich,Robert C. Borer,Robert C. Borer,Werner N. Keidel,Werner N. Keidel +7 more
TL;DR: General principles of acetone precipitation are presented as a guide in clinical interpretation of the L/S ratio and evidence is presented that there is continuity between the fetal lungs and amniotic fluid.
Journal ArticleDOI
The lung profile. II. Complicated pregnancy
Marie V. Kulovich,Louis Gluck +1 more
TL;DR: The lung profile in amniotic fluid was studied in relation to various classes of diabetes, to prolonged rupture of membranes, and to hypertension in pregnancy as mentioned in this paper, and a statistically significant acceleration of maturation affecting both the L/S ratio and PG appeared early.
References
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Journal ArticleDOI
Diagnosis of the respiratory distress syndrome by amniocentesis
Louis Gluck,Marie V. Kulovich,Robert C. Borer,Paul H. Brenner,Gerald G. Anderson,William N. Spellacy +5 more
TL;DR: Studies on 302 amniocenteses show that changes in phospholipids in amniotic fluid reflect those in the lung of the developing fetus, and a sudden increase in lecithin concentration after 35 weeks heralds maturity of the pulmonary alveolar lining when respiratory distress syndrome will not occur should the fetus then be born.
Journal ArticleDOI
Observations on heart rate and pH in the human fetus during labor
TL;DR: Eighty-five human fetuses were studied during labor by continuously monitoring the fetal heart rate and uterine contractions and correlating FHR patterns with 218 averaged values of fetal pH derived from 618 single samples, finding specific FHR deceleration patterns are definitely associated with disturbances in acid-base balance.
Journal ArticleDOI
Clinical experience with the oxytocin challenge test
TL;DR: In instances where the 24 hour urinary estriol excretion is chronically low and therefore of questionable value in timing delivery, the test provides a physiologic stress to the fetus, the response to which may reflect the degree of fetoplacental respiratory reserve.
Journal ArticleDOI
Adrenal gland structure and the development of hyaline membrane disease
TL;DR: Analysis of 387 consecutive autopsies on human neonates demonstrated that adrenal glands were 19% lighter in infants with hyaline membrane disease than in those without the disorder, owing to a greater number of adrenal cortical cells in the latter infants.
Journal ArticleDOI
Estriol in pregnancy. II. Daily urinary estriol assays in the management of the pregnant diabetic woman.
TL;DR: In pregnant diabetic subjects, urinary E3 assays should be carried out daily if the obstetric management is based upon E3 determinations, and patient-to-patient differences in E3 excretion were greater among diabetic gravidas than in normal women.
Related Papers (5)
Lecithin/sphingomyelin ratios in amniotic fluid in normal and abnormal pregnancy☆
Louis Gluck,Marie V. Kulovich +1 more