Open AccessDissertation
Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family
About:
The article was published on 2009-01-01 and is currently open access. It has received 78 citations till now. The article focuses on the topics: Cancer & Clinical significance.read more
Citations
More filters
Journal ArticleDOI
Targeting microRNAs in cancer: rationale, strategies and challenges.
TL;DR: The role of miRNAAs in tumorigenesis is described and the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer are critically discussed.
Journal ArticleDOI
Circulating microRNAs in plasma of patients with gastric cancers
Masahiro Tsujiura,Daisuke Ichikawa,Shuhei Komatsu,Atsushi Shiozaki,Hideyuki Takeshita,Toshiyuki Kosuga,Hirotaka Konishi,R Morimura,K Deguchi,Hitoshi Fujiwara,Kazuma Okamoto,Eigo Otsuji +11 more
TL;DR: Detection of circulating miRNAs might provide new complementary tumour markers for GC, and they were significantly reduced in post-operative samples.
Journal ArticleDOI
Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression
TL;DR: It is proposed that steps of tumor progression can be viewed as a continuum of progressive dedifferentiation (EMT) with a cell at the endpoint that has stem cell-like properties and steps of this process are driven by specific changes in the expression of let-7 and miR-200 family members.
Journal ArticleDOI
The roles of microRNA in cancer and apoptosis
TL;DR: Emerging evidence supporting a role for miRNAs in modulating sensitivity to anti‐cancer therapy is considered, specifically those mi RNAs involved in the regulation of apoptotic pathways and tumour suppressor/oncogene networks.
Journal ArticleDOI
MicroRNA dysregulation in gastric cancer: a new player enters the game
TL;DR: Elucidating the biological aspects of miRNA dysregulation may help to better understand the pathogenesis of gastric cancer and promote the development of mi RNA-directed therapeutics against this deadly disease.
References
More filters
Journal ArticleDOI
Targeting microRNAs in cancer: rationale, strategies and challenges.
TL;DR: The role of miRNAAs in tumorigenesis is described and the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer are critically discussed.
Journal ArticleDOI
Circulating microRNAs in plasma of patients with gastric cancers
Masahiro Tsujiura,Daisuke Ichikawa,Shuhei Komatsu,Atsushi Shiozaki,Hideyuki Takeshita,Toshiyuki Kosuga,Hirotaka Konishi,R Morimura,K Deguchi,Hitoshi Fujiwara,Kazuma Okamoto,Eigo Otsuji +11 more
TL;DR: Detection of circulating miRNAs might provide new complementary tumour markers for GC, and they were significantly reduced in post-operative samples.
Journal ArticleDOI
Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression
TL;DR: It is proposed that steps of tumor progression can be viewed as a continuum of progressive dedifferentiation (EMT) with a cell at the endpoint that has stem cell-like properties and steps of this process are driven by specific changes in the expression of let-7 and miR-200 family members.
Journal ArticleDOI
The roles of microRNA in cancer and apoptosis
TL;DR: Emerging evidence supporting a role for miRNAs in modulating sensitivity to anti‐cancer therapy is considered, specifically those mi RNAs involved in the regulation of apoptotic pathways and tumour suppressor/oncogene networks.
Journal ArticleDOI
MicroRNAs in Human Pituitary Adenomas
TL;DR: The deregulated miRNAs and their targets are summarized to shed more light on their potential as therapeutic targets and novel biomarkers in pituitary adenoma progression.