Book ChapterDOI
Complex Learning and Memory
Carl W. Cotman,James L. McGaugh +1 more
- pp 295-348
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TLDR
This chapter describes complex learning and memory in humans and discusses the effects of brain lesions on retention and neurobiological correlates of memory.Abstract:
This chapter describes complex learning and memory in humans. Learning and memory involve a complex set of processes by which experiences alter the nervous system in ways such that the changes endure and effect subsequent experience and behavior. Memory does not consist simply of responses made during learning. Humans readily learn and perform skills such as language in which responses occur in novel sequence. The memory can be indicated by speaking, dialing, pushing buttons or in other ways, such as writing or simply identifying the sequence of numbers as the correct number. The memory is formed rapidly, is usually transient, but, with rehearsal or repetition, can become long-lasting. This chapter reviews approaches to the neurobiological bases of memory. The chapter discusses the effects of brain lesions on retention and neurobiological correlates of memory.read more
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Journal ArticleDOI
Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
Journal ArticleDOI
Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.
TL;DR: A previous investigation showed that bilateral or unilateral cooling of the pre-frontal cortical convexity produces marked and reversible deficits of performance in animals trained at the direct-method version of the delayed-response test, so the same test was adopted for the present study.
Journal ArticleDOI
Acquisition of motor skill after bilateral medial temporal-lobe excision
TL;DR: In this paper, the acquisition of selected motor skills was studied in a 40-year-old man with a severe amnestic syndrome resulting from a bilateral medial temporal-lobe resection carried out 13 years before.
Journal ArticleDOI
Hippocampal electrical activity during the development of conditioned reflexes
TL;DR: The conclusion is advanced that the hippocampus plays an essential role in the inhibition of the orientative reflex and in the stabilization of the temporary connection, which would explain the role of hippocampal lesions in the development of Korsakoff's syndrome.