Journal ArticleDOI
Corneal Absorption Reinforcement of Certain Mydriatics
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TLDR
The results of the animal experimentation indicated that the several biological buffers tested [tromethamine, 2-morpholino)ethanesulfonic acid, and N, N-bis(2-hydroxyethyl)glycine] were not as effective as sodium borate for increasing the corneal absorption of the medicinal agents used.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1970-11-01. It has received 13 citations till now. The article focuses on the topics: Ethanesulfonic acid.read more
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Journal ArticleDOI
Lacrimal and Instilled Fluid Dynamics in Rabbit Eyes
TL;DR: It is suggested that drainage rates of instilled solutions in humans should be larger than those of rabbits; therefore, to maximize activity of drugs in humans, the drop size of ophthalmic delivery systems ought to be reduced from its present 50–75-μl.
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pKa Values of Medicinal Compounds in Pharmacy Practice
David W. Newton,Ronald B. Kluza +1 more
TL;DR: A brief review of pKa values and their uses in pharmacy practice is presented and adequate literature sources are included to permit further reference to the more detailed aspects of conditions associated with pKa value determinations or uses.
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The effect of different ophthalmic vehicles on the activity of tropicamide in man.
TL;DR: The most common vehicles for topical ophthalmic drugs are ‘regular’ saline solutions, viscous saline solutions and semisolid paraffin ointments andSemisolid aqueous gels are seldom used clinically, in spite of evidence of greatly enhanced therapeutic responses in the rabbit.
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Plasma concentrations and ocular effects of cyclopentolate after ocular application of three formulations.
TL;DR: The cycloplegic response was more intense after one of the polygalacturonate complexes, especially at later time points, and the maximal mydriatic effect was reached within about 15 min and was maintained for several hours, often being 1/3 of its peak value after 30 h.
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Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics
TL;DR: This review of the literature represents a comprehensive cross section of the research and development efforts in various selected disciplines of the pharmaceutical sciences.
References
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Journal ArticleDOI
Hydrogen ion buffers for biological research.
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Precipitous Mental Deterioration Following Cycloplegia With 0.2% Cyclopentolate HC1
TL;DR: An 82-year-old man showed a decompensation of a previously compensated chronic dementia following instillation of four drops of a solution of 0.2% cyclopentolate hydrochloride, 1% phenylephrine hydro chloride, with 3% polyvinylpyrrolidone in buffered isotonic base.
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Buffering technique for obtaining increased physiological response from alkaloidal eye-drops.
TL;DR: It is widely accepted that the physiological activity of alkaloidal eye preparations results from the penetration through the cornea of the free base portion rather than of the ionic form of the alkaloid, which necessitates the use of larger doses to obtain the desired physiological response for many alkaloids.
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To dilate or not to dilate.
TL;DR: The more common of the two diseases, open angle glaucoma, is chronic, asymptomatic, and a major cause of blindness, and it is not seriously affected by mydriatic drops instilled for a single examination.