Book ChapterDOI
Cross-Coupling Reaction
M. Zaidlewicz,J. Meller +1 more
- pp 1
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The article was published on 2005-01-01. It has received 52 citations till now. The article focuses on the topics: Elementary reaction & Stepwise reaction.read more
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Journal ArticleDOI
PEG-400 promoted Pd(OAc)2/DABCO-catalyzed cross-coupling reactions in aqueous media
TL;DR: In this paper, a polyethylene glycol-400 (PEG-400) was used to improve the Pd(OAc)2/DABCO-catalyzed Suzuki-Miyaura and Stille cross-coupling reactions.
Journal ArticleDOI
Suzuki–Miyaura cross-coupling reaction of aryl bromides and chlorides with phenylboronic acid under aerobic conditions catalyzed by palladium complexes with thiosemicarbazone ligands
Ioannis D. Kostas,Fotini J. Andreadaki,Dimitra Kovala-Demertzi,Christos Prentjas,Mavroudis A. Demertzis +4 more
TL;DR: For example, in this paper, palladium complexes with salicylaldehyde thiosemicarbazones were applied as catalyst precursors to the Suzuki-Miyaura reaction.
Journal ArticleDOI
Recyclable and highly active cationic 2,2′-bipyridyl palladium(II) catalyst for Suzuki cross-coupling reaction in water
TL;DR: A water-soluble and air-stable palladium(II)/cationic 2,2′-bipyridyl catalyst is proven to be a recyclable and extremely active catalyst for Suzuki reaction in aqueous and aerobic conditions as mentioned in this paper.
Journal ArticleDOI
Ligand-free Pd catalyzed cross-coupling reactions in an aqueous hydrotropic medium
TL;DR: In this paper, a simple, efficient and ligand-free protocol for the Suzuki-Miyaura reaction and base-free Heck-Matsuda reactions under mild reaction conditions has been developed over palladium supported on activated carbon (Pd/C) in an aqueous hydrotropic solution.
Journal ArticleDOI
Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Robert G. Gentles,Min Ding,Bender John A,Bergstrom Carl P,Katharine A. Grant-Young,Piyasena Hewawasam,Thomas W. Hudyma,Scott W. Martin,Andrew Nickel,Alicia Regueiro-Ren,Yong Tu,Zhong Yang,Kap-Sun Yeung,Xiaofan Zheng,Sam T. Chao,Jung-Hui Sun,Brett R. Beno,Daniel M. Camac,Chong-Hwan Chang,Mian Gao,Paul E. Morin,Steven Sheriff,Jeff Tredup,John Wan,Mark R. Witmer,Dianlin Xie,Umesh Hanumegowda,Jay O. Knipe,Kathy Mosure,Kenneth S. Santone,Dawn D. Parker,Xiaoliang Zhuo,Julie A. Lemm,Mengping Liu,Lenore A. Pelosi,Karen Rigat,Voss Stacey A,Yi Wang,Ying-Kai Wang,Richard J. Colonno,Min Gao,Susan B. Roberts,Qi Gao,Alicia Ng,Nicholas A. Meanwell,John F. Kadow +45 more
TL;DR: Structural-activity relationship studies resulted in the optimization of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors, and analogues exhibiting improved solubility and membrane permeability were shown to have notably enhanced pharmacokinetic profiles.