Journal ArticleDOI
Dengue 2 Virus NS2B and NS3 Form a Stable Complex That Can Cleave NS3 within the Helicase Domain
TLDR
An NS3-specific antiserum is used, under nondenaturing conditions, to demonstrate that NS2B and NS3 form a complex both in vitro and in vivo, and a potential conserved cleavage site that resembles other sites cleaved by the NS3/NS2B proteinase is revealed.About:
This article is published in Virology.The article was published on 1993-04-01. It has received 188 citations till now. The article focuses on the topics: NS3 & Sequence motif.read more
Citations
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Flaviviridae :T he Viruses and Their Replication
TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
Book ChapterDOI
Molecular biology of flaviviruses.
TL;DR: An overview of the molecular biology of the flaviviruses is presented, which are enveloped positive-strand RNA viruses capable of causing a number of important human diseases.
Journal ArticleDOI
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.
TL;DR: The data suggest that HCV NS4A may be the functional analog of flavivirus NS2B and pestivirus p10 proteins and thatNS4A can activate the NS3 protease when supplied in trans.
Journal ArticleDOI
Yellow fever vaccine
TL;DR: The genus Flavivirus is a member of the family Flaviviridae, a group of small, enveloped, positive-sense, single-strand RNA viruses as mentioned in this paper.
Journal ArticleDOI
Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures.
TL;DR: The subcellular location of the nonstructural proteins NS1, NS2B, and NS3 in Vero cells infected with the flavivirus Kunjin was investigated using indirect immunofluorescence and cryoimmunoelectron microscopy with monospecific antibodies.