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Detailed Simulation of the Cochlea: Recent Progress Using Large Shared Memory Parallel Computers

TLDR
A detailed three-dimensional computational model of the human cochlea is developed and refined, which uses the immersed boundary method to calculate the fluid-structure interactions produced in response to incoming sound waves.
Abstract
We have developed and are refining a detailed three-dimensional computational model of the human cochlea. The model uses the immersed boundary method to calculate the fluid-structure interactions produced in response to incoming sound waves. An accurate cochlear geometry obtained from physical measurements is incorporated. The model includes a detailed and realistic description of the various elastic structures present. Initially, a macro-mechanical computational model was developed for execution on a CRAY T90 at the San Diego Supercomputing Center. This code was ported to the latest generation of shared memory high performance servers from Hewlett Packard. Using compiler generated threads and OpenMP directives, we have achieved a high degree of parallelism in the executable, which has made possible to run several large scale numerical simulation experiments to study the interesting features of the cochlear system. In this paper, we outline the methods, algorithms and software tools that were used to implement and fine tune the code, and discuss some of the simulation results.

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Citations
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A stochastic immersed boundary method for fluid-structure dynamics at microscopic length scales

TL;DR: The theoretical analysis and numerical results show that the immersed boundary method with thermal fluctuations captures many important features of small length scale hydrodynamic systems and holds promise as an effective method for simulating biological phenomena on the cellular and subcellular length scales.
Journal ArticleDOI

Modelling Cochlear Mechanics

TL;DR: This paper focuses on reviewing the numerical modelling of the mechanical and electrical processes in the cochlea, which include fluid coupling, micromechanics, the co chlear amplifier, nonlinearity, and electrical coupling.
Journal ArticleDOI

Distributed Immersed Boundary Simulation in Titanium

TL;DR: A parallelized algorithm for the immersed boundary method that is designed for scalability on distributed memory multiprocessors and clusters of SMPs, implemented using the Titanium language, a Java-based language designed for high performance scientific computing.
Journal ArticleDOI

Quantitative reappraisal of the helmholtz-guyton resonance theory of frequency tuning in the cochlea.

TL;DR: A quantitative rendition of the classical Helmholtz-Guyton model captures the essence of cochlear mechanics and unifies the competing resonance and traveling wave theories.
Journal ArticleDOI

Three-dimensional modeling of the cochlea by use of an arc fitting approach.

TL;DR: The proposed cochlea modeling approach is presented allowing for a user defined degree of geometry simplification which automatically adjusts to the patient specific anatomy and is well suited for a wide range of applications including finite element analyses where geometric simplifications are often inevitable.
References
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Journal ArticleDOI

Hearing. II. The Physical Basis of the Action of the Cochlea

TL;DR: In this article, it is shown that the assumption of a 9passive 9 cochlea, where elements are brought into mechanical oscillation solely by means of the incident sound, is not tenable, and it is suggested that an electromechanical action takes place whereby a supply of electrical energy is employed to counteract the damping.
Journal Article

A general method for the computer simulation of biological systems interacting with fluids.

TL;DR: The immersed boundary method is described, which is a general framework for the computer simulation of biofluid dynamic systems and has already been applied to blood flow in the heart, platelet aggregation during blood clotting, aquatic animal locomotion, wave propagation along the basilar membrane of the inner ear, and flow in collapsible tubes.
Journal ArticleDOI

Three-dimensional numerical modeling for global cochlear dynamics

TL;DR: A hybrid analytical-numerical model using Galerkin approximation to variational equations has been developed for predicting global cochlear responses and it is shown that basilar membrane velocity close to best place is influenced by fluid and structural discretization.
Journal ArticleDOI

Finite element micromechanical modeling of the cochlea in three dimensions

TL;DR: Results are presented which demonstrate the effect of tectorial membrane and Deiters' cell mechanical properties on the effectiveness of the cochlear amplifier.
Posted Content

Modeling Elasstic Shells Immersed in Fluid

TL;DR: In this paper, the authors describe a numerical method to simulate an elastic shell immersed in a viscous incompressible fluid, which is an extension of the immersed boundary method using shell equations based on the Kirchhoff Love and the planar stress hypotheses.
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