Dietary patterns and risk of colorectal tumors: a cohort of French women of the National Education System (E3N)
Reads0
Chats0
TLDR
Dietary patterns that reflect a Western way of life are associated with a higher risk of colorectal tumors.Abstract:
Little is known about the dietary patterns associated with colorectal tumors along the adenoma-carcinoma sequence. Scores for dietary patterns were obtained by factor analysis in women from the French cohort of the European Prospective Investigation into Cancer and Nutrition (1993-2000). Their association with colorectal tumors was investigated in 516 adenoma cases (175 high-risk adenomas) and 4,804 polyp-free women and in 172 colorectal cancer cases and 67,312 cancer-free women. The authors identified four dietary patterns: "healthy" (vegetables, fruit, yogurt, sea products, and olive oil); "Western" (potatoes, pizzas and pies, sandwiches, sweets, cakes, cheese, cereal products, processed meat, eggs, and butter); "drinker" (sandwiches, snacks, processed meat, and alcoholic beverages); and "meat eaters" (meat, poultry, and margarine). For quartile 4 versus quartile 1, an increased risk of adenoma was observed with high scores of the Western pattern (multivariate relative risk (RR) = 1.39, 95% confidence interval: 1.00, 1.94; p(trend) = 0.03) and the drinker pattern (RR = 1.42, 95% confidence interval: 1.10, 1.83; p(trend) = 0.01). The meat-eaters pattern was positively associated with colorectal cancer risk (for quartile 4 vs. quartile 1: RR = 1.58, 95% confidence interval: 0.98, 2.53; p(trend) = 0.02). Dietary patterns that reflect a Western way of life are associated with a higher risk of colorectal tumors.read more
Citations
More filters
Journal ArticleDOI
Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese.
Jie Ge,Lin Zhu,Junde Zhou,Guangxiao Li,Ye Li,Shuying Li,Zhiwei Wu,Jiesheng Rong,Huiping Yuan,Yanhong Liu,Qiang Chi,Daxun Piao,Yashuang Zhao,Binbin Cui +13 more
TL;DR: These data indicate potential associations between BTLA and PD-1 polymorphisms and CRC susceptibility and the three co-inhibitory molecule gene SNPs have environmental interactions associated with CRC risk.
Posted ContentDOI
Interaction Between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer
TL;DR: It is found that miRNAs correlated with CRC-associated bacteria are predicted to regulate targets that are relevant for host-microbiome interactions, and highlight a possible role for miRNA-driven glycan production in the recruitment of pathogenic microbial taxa.
Journal ArticleDOI
Dietary patterns and colorectal cancer: a case-control study from Portugal.
TL;DR: The results confirm the higher risk of colorectal cancer among subjects with ‘western’ diets and ‘low consumption of milk and foods containing foods containing dietary fiber’ and support public health messages based on the accumulated evidence on the relationship between individual food items/groups and colore CT cancer.
Journal ArticleDOI
Structure of the Mucosal and Stool Microbiome in Lynch Syndrome.
Yan Yan,David A. Drew,Arnold J. Markowitz,Jason Lloyd-Price,Jason Lloyd-Price,Galeb Abu-Ali,Galeb Abu-Ali,Long H. Nguyen,Christina Tran,Daniel C. Chung,Katherine K. Gilpin,Dana Meixell,Melanie P. Parziale,Madeline M. Schuck,Zalak Patel,James M. Richter,Peter B. Kelsey,Wendy S. Garrett,Andrew T. Chan,Zsofia K. Stadler,Curtis Huttenhower,Curtis Huttenhower +21 more
TL;DR: Predictive transcripts corresponded with a shift in flagellin contributors and oxidative metabolic microenvironment, potentially factors in local CRC pathogenesis, which suggests that the effectiveness of prospective microbiome monitoring for adenomas may be limited but supports the potential causality of these consistent, early microbial changes in colonic neoplasia.
Journal ArticleDOI
Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association
TL;DR: This review summarizes and discusses major findings of the area in the context of potentially pertinent mechanisms underlying the association between consumption of red/processed meat and increased risk of developing CRC.
References
More filters
Journal ArticleDOI
Dietary pattern analysis: a new direction in nutritional epidemiology.
TL;DR: The rationale for studying dietary patterns is described, quantitative methods for analysing dietary patterns and their reproducibility and validity are discussed, and the available evidence regarding the relationship between major Dietary patterns and the risk of cardiovascular disease is discussed.
Book
Cancer Epidemiology and Prevention
TL;DR: This is an account of cancer epidemiology has been expanded and contains new material on cancer biology, molecular epidemiology, preventive strategies and specific types and sites of cancer.
Journal ArticleDOI
Critique of Report on "Food, Nutrition and the Prevention of Cancer: A Global Perspective"
Journal ArticleDOI
Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk
Elio Riboli,Teresa Norat +1 more
TL;DR: Prospective studies provide weaker evidence than case-control studies of the association of fruit and vegetable consumption with reduced cancer risk, and the association may have been underestimated in prospective studies because of the combined effects of imprecise dietary measurements and limited variability of dietary intakes within each cohort.