Journal ArticleDOI
Diferencias farmacocinéticas entre hombres y mujeres
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This article is published in FMC - Formación Médica Continuada en Atención Primaria.The article was published on 2013-06-01. It has received 0 citations till now.read more
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Journal ArticleDOI
Sex-based differences in the effect of digoxin for the treatment of heart failure.
TL;DR: Digoxin therapy is associated with an increased risk of death from any cause among women, but not men, with heart failure and depressed left ventricular systolic function.
Journal ArticleDOI
Sex Differences in Pharmacokinetics and Pharmacodynamics
TL;DR: This review examines the biologic basis of differences in pharmacokinetics and pharmacodynamics between the sexes and summarizes studies that have addressed these differences.
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How Important Are Gender Differences in Pharmacokinetics
TL;DR: Gender-related differences in pharmacokinetics have frequently been considered as potentially important determinants for the clinical effectiveness of drug therapy and intensive future research efforts are needed to assess the full scope and impact of pharmacodynamic gender disparity on applied pharmacotherapy.
Journal ArticleDOI
Gender differences in drug responses
TL;DR: This review summarizes gender differences (GDs) in drug response and considers whether sex has to be considered in order to improve drug safety efficacy and to optimize medical therapy both in men and women.
Journal ArticleDOI
Diazepam disposition determinants.
David J. Greenblatt,David J. Greenblatt,David J. Greenblatt,Marcia Divoll Allen,Marcia Divoll Allen,Marcia Divoll Allen,Jerold S. Harmatz,Jerold S. Harmatz,Jerold S. Harmatz,Richard I. Shader,Richard I. Shader,Richard I. Shader +11 more
TL;DR: Plasma diazepam concentrations were determined by electron‐capture gas‐liquid chromatography in multiple samples drawn for as long as 9 days after a single 5‐ to 10‐mg intravenous dose, and volume of distribution became larger both with increasing age and with female sex.