Journal ArticleDOI
Digoxin in the elderly: Pharmacokinetic consequences of old age
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TLDR
Both absolute and weight‐corrected values for plasma clearance of digoxin were reduced in the elderly subjects, and the absolute apparent volume of distribution was reducing in the older patients and correlated inversely with age.Abstract:
A study of single-dose digoxin kinetics was performed in 6 young and 7 elderly patients. The rate of absorption, determined by the time to peak concentration after an oral dose, was more rapid in the younger group. The extent of absorption, as measured by comparison of the area under the plasma concentration/time curve after oral and intravenous administration, was similar in both groups. Mean plasma half-life was longer and individual values were more variable in the elderly patients. The absolute apparent volume of distribution was reduced in the older patients and correlated inversely with age. When corrected for weight, however, the difference in the apparent volume of distribution did not approach significance. Both absolute and weight-corrected values for plasma clearance of digoxin were reduced in the elderly subjects.read more
Citations
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Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications
TL;DR: This review focuses on the main age-related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.
Journal ArticleDOI
Drug Disposition in Old Age
TL;DR: The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern.
Journal ArticleDOI
Management of Drug Therapy in the Elderly
TL;DR: There has been relatively little investigation of the effects of age at the sites of drug action, and little information is available about drug disposition and response in the elderly.
Journal ArticleDOI
Prescribing for the Elderly Part I: Sensitivity of the Elderly to Adverse Drug Reactions*
Lisa Nolan,Kevin O'Malley +1 more
TL;DR: The evidence for a relationship between chronological age and adverse drug reactions is reviewed and the contribution of related factors, such as multiple drug therapy and increased morbidity, are evaluated.
Journal ArticleDOI
Drug therapy in the elderly.
TL;DR: The recommendations for clinical practice and directions for future research that are presented should help make drug therapy in the elderly safer and more effective.
References
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Journal ArticleDOI
Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males
Dean F. Davies,Nathan W. Shock +1 more
Journal ArticleDOI
Adult lean body mass declines with age: some longitudinal observations.
Gilbert B. Forbes,Julio C. Reina +1 more
TL;DR: The magnitude of the decline in Lean body mass, as estimated from 40 K counting, declines progressively during adult life, and the sex difference in LBM great enough to suggest that age and sex should both be taken into account in such matters as drug dosage and nutritional requirements.
Journal ArticleDOI
Intensive hospital monitoring of adverse reactions to drugs.
Natalie Hurwitz,O. L. Wade +1 more
TL;DR: Though only four reactions were of life-threatening seriousness, 80% of the 129 reactions observed were of moderate severity, and it is suggested that larger surveys of adverse reactions in relation to drug usage would make a useful contribution to the problem.
Journal ArticleDOI
Digoxin Metabolism in the Elderly
TL;DR: The same dose of tritiated digoxin resulted in higher blood concentrations and longer blood half-life in the elderly, due to the smaller body size and a diminished urinary excretion of digoxin inThe elderly.
Journal ArticleDOI
A nomogram for digoxin therapy
Roger W. Jelliffe,Gary Brooker +1 more
TL;DR: A nomogram is described for developing loading and maintenance dosage regimens of digoxin for adult euthyrold patients with reasonably normal hepatic function, in normal electrolyte balance, who have no obvious abnormality of gastrointestinal absorption.