Doppler ultrasound evaluation in preeclampsia
Maria A Lopez-Mendez,Victoria Martinez-Gaytan,Raúl Cortés-Flores,René Ramos-González,Mauro A Ochoa-Torres,Idalia Garza-Veloz,Monica I. Martinez-Acuna,Jose I. Badillo-Almaraz,Margarita L Martinez-Fierro +8 more
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TLDR
General Doppler US result, as well as N from uterine vessel, RI from umbilical artery, and PI from Umbilical and middle cerebral arteries in their individual form, may be considered as tools to determine hemodynamic repercussion caused by PE.Abstract:
Worldwide preeclampsia (PE) is the leading cause of maternal death and affects 5 to 8% of pregnant women. PE is characterized by elevated blood pressure and proteinuria. Doppler Ultrasound (US) evaluation has been considered a useful method for prediction of PE; however, there is no complete data about the most frequently altered US parameters in the pathology. The aim of this study was to evaluate the uterine, umbilical, and the middle cerebral arteries using Doppler US parameters [resistance index (RI), pulsatility index (PI), notch (N), systolic peak (SP) and their combinations] in pregnant women, in order to make a global evaluation of hemodynamic repercussion caused by the established PE. A total of 102 pregnant Mexican women (65 PE women and 37 normotensive women) were recruited in a cases and controls study. Blood velocity waveforms from uterine, umbilical, and middle cerebral arteries, in pregnancies from 24 to 37 weeks of gestation were recorded by trans-abdominal examination with a Toshiba Ultrasound Power Vision 6000 SSA-370A, with a 3.5 MHz convex transducer. Abnormal general Doppler US profile showed a positive association with PE [odds ratio (OR) = 2.93, 95% confidence interval (CI) = 1.2 - 7.3, P = 0.021)], and a specificity and predictive positive value of 89.2% and 88.6%, respectively. Other parameters like N presence, RI and PI of umbilical artery, as well as the PI of middle cerebral artery, showed differences between groups (P values < 0.05). General Doppler US result, as well as N from uterine vessel, RI from umbilical artery, and PI from umbilical and middle cerebral arteries in their individual form, may be considered as tools to determine hemodynamic repercussion caused by PE.read more
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Journal ArticleDOI
Uterine and umbilical artery doppler in women with pre-eclampsia and their pregnancy outcomes
TL;DR: The uterine artery PI is the best predictor of Pre-eclampsia, whereas the combinations of uterine and umbilical arteries PSV best predict severity of PE among high-risk pregnant Nigeria women.
Journal ArticleDOI
Maternal vascular responses to hypoxia in a rat model of intrauterine growth restriction
TL;DR: Although there was a compensatory reduction in uterine artery RI in the hypoxia groups, this was not sufficient to prevent IUGR, and these data demonstrate maternal and fetal alterations in vascular function due to prenatal exposure to Hypoxia.
Journal ArticleDOI
Pregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction.
Terri A. Levine,Ruth E. Grunau,Ricardo Segurado,Sean Daly,Michael Geary,Mairead Kennelly,Keelin O'Donoghue,Alyson Hunter,John J. Morrison,Gerard Burke,Patrick Dicker,Elizabeth Tully,Fergal D. Malone,Fiona Alderdice,Fionnuala M. McAuliffe +14 more
TL;DR: It is suggested that fetoplacental haemodynamics may be a mechanistic link between maternal prenatal stress and fetal and neonatal well-being, but additional research is required.
Journal ArticleDOI
Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia
Laura E. Coats,Daniel R Bamrick-Fernandez,Allison M Ariatti,Bhavisha A. Bakrania,Adam Z Rawls,Norma B. Ojeda,Barbara T. Alexander +6 more
TL;DR: The efficacy of Riociguat, a sGC stimulator, in IUGR reversion in the RUPP rat model of PE is demonstrated and the hypothesis that improvement in fetal weight occurs in association with improvement in placental perfusion, placental morphology, and placental nutrient transport protein expression is tested.
Journal ArticleDOI
Utility of Cerebroplacental Ratio in IUGR Fetuses from Pregnancy with Preeclampsia in Prediction the Risk for Perinatal Complications.
M. Novac,Amira Moldoveanu,Stefania Tudorache,Nuţi Daniela Oprescu,Mihaela Miescu,Mirela Anişoara Siminel,Sidonia Vrabie,Marius Bogdan Novac,Dominic Gabriel Iliescu +8 more
TL;DR: This study shows that early onset severe PE and concomitantly IUGR affects a significant proportion of pregnancies and can be used to identify fetuses with an increased risk of intrauterine compromise.
References
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Reference ranges for uterine artery mean pulsatility index at 11–41 weeks of gestation
Olga Gómez,Francesc Figueras,S. Fernandez,Mar Bennasar,J. M. Martínez,Bienvenido Puerto,Eduard Gratacós +6 more
TL;DR: To construct gestational age (GA)‐based reference ranges for the uterine artery (UtA) mean pulsatility index (PI) at 11–41 weeks of pregnancy, the mean pulsatile index was calculated by subtracting the age of the mother and the child from the patient to construct reference ranges.
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Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array.
TL;DR: According to the findings, preeclampsia was associated with an overall pro-inflammatory systemic environment and Elevated amounts of pro- inflammatory cytokines, chemokines and adhesion molecules in the maternal circulation might play a central role in the excessive systemic inflammatory response, as well as in the generalized endothelial dysfunction characteristics of the maternal syndrome of preeclamping.