Journal ArticleDOI
DYNAMICS OF SERUM rT3 AND 3, 3‐T2 DURING rT3 INFUSION IN PATIENTS TREATED FOR THYROTOXICOSIS WITH PROPYLTHIOURACIL OR METHIMAZOLE
Peter Laurberg,Jørgen Weeke +1 more
TLDR
rT3 metabolism in patients treated for thyrotoxicosis with propylthiouracil (PTU), or methimazole (MMI) was studied by infusion of rT 3 and measurements of the increase in serum rT3 and serum 3, 3′‐diiodothyronine.Abstract:
SUMMARY
rT3 metabolism in patients treated for thyrotoxicosis with propylthiouracil (PTU), or methimazole (MMI) was studied by infusion of rT3 and measurements of the increase in serum rT3 and serum 3, 3′-diiodothyronine.
The results indicate that the high serum rT3 observed during treatment with PTU is not due to an increase in rT3 production, but to a decrease in the metabolic clearance rate of rT3. rT3 infusion was followed by an increase in serum 3, 3′-T2 which was similar whether PTU or MMI was given. However, after stopping rT3 infusion there was a more rapid fall in serum 3, 3′-T2 during MMI treatment, compatible with an inhibitory effect of PTU on 3, 3′-T2 degradation.read more
Citations
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Journal ArticleDOI
Neonatal Thyroid Function after Propylthiouracil Therapy for Maternal Graves' Disease
TL;DR: Low doses of PTU, 300 mg or less daily, are thought to afford satisfactory control of maternal hyperthyroidism and are not believed to cause clinically evident thyroid dysfunction in the neonate.
Journal ArticleDOI
Serum triiodothyronine sulfate in man measured by radioimmunoassay.
TL;DR: Low serum T3S concentrations are detected in humans given T3 in normal subjects and the low ratio in humans may indicate that sulfate conjugation of thyroid hormone in humans is not an important mechanism of T3 metabolism in humans and/or the kinetics of plasma T3 and T3
Journal ArticleDOI
Handling of iodothyronines by the liver and kidney in patients with chronic liver disease.
TL;DR: Estimates of hepatic and renal plasma flow were in agreement with values from the literature and possible arterio-venous gradients across the liver and the kidneys were measured in 9 patients with varying degrees of liver failure undergoing diagnostic catheterization.
Journal ArticleDOI
Three-compartmental analysis of effects of D-propranolol on thyroid hormone kinetics.
TL;DR: Tracer thyroxine (T4), 3.3',5-triiodothyronine (tT3), and 3,3,5'-triiodine (rT3) kinetic studies were performed in normal T4 substituted subjects before and during oral D-propranolol treatme...
Journal ArticleDOI
Thyroid hormone secretion rates: response to endogenous and exogenous TSH in man during surgery
TL;DR: The results indicate that TSH induces preferential secretion of triiodothyronines in man, and this response correlated with the area under the curve of the TSH serum concentration.
References
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Journal ArticleDOI
Iodothyronine Metabolism in Rat Liver Homogenates
TL;DR: The data suggest that one iodothyronine 5'-deiodinase is responsible for both T(4) to T(3) conversion and rT( 3) degradation in liver and, perhaps, in kidney.
Journal ArticleDOI
Review: the use of isotopic steroids for the measurement of production rates in vivo.
TL;DR: The most obvious purpose of the use of isotopic steroids to obtain secretion rates in vivohas been to minimize the disturbance caused by the observation to the prevailing secretion rate.
Journal ArticleDOI
An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man.
TL;DR: While 3, 3', 5'-triiodothyronine (reverse T3, rT3) has been detected both in human serum and in thyroglobulin, no quantitative assessment of its metabolic clearance rate (MCR), production rate (PR), or secretion by the thyroid is yet available, this study examines this information in euthyroid subjects and evaluates it in light of similar information about two other iodothyronines in the thyroid.
Journal ArticleDOI
Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone.
TL;DR: The data suggest that monodeiodination of T(4) but not of T-triiodothyronine is essential before hormonal effects can be manifested at the cellular level, and provides a possible explanation of the many published observations indicating that PTU antagonizes the tissue effects of L-thyroxine but not T(3).
Journal ArticleDOI
Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.
TL;DR: The data suggest that PTU blocks extrathyroidal conversion of T4 to T3, thus increasing pituitary TSH secretion and augmenting the TSH response to TRH.
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