Effect of bile salts on ionic movement across the human gastric mucosa.
Kevin J. Ivey,Kevin J. Ivey,Lawrence DenBesten,Lawrence DenBesten,James A. Clifton,James A. Clifton +5 more
TLDR
The authors compared ionic fluxes across the human gastric mucosa after serial instillation of 200ml of 5.0 to 5.5mm bile salts in HCl (160 milliequivalents per liter) solution to those after serialinstillation of HC1 alone (controls) in 9 normal subjects.About:
This article is published in Gastroenterology.The article was published on 1970-11-01 and is currently open access. It has received 149 citations till now. The article focuses on the topics: Taurocholic acid & Taurodeoxycholic acid.read more
Citations
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Measurements of Intestinal Permeability Using Low Molecular Weight Polyethylene Glycols (PEG 400): II. Application to normal and abnormal permeability states in man and animals
TL;DR: Successful assessments of gastric, jejunal, ileal, and colonic permeability suggest that the PEG 400 technique has application to any area of the gastrointestinal tract.
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Back-diffusion of CO2 and its influence on the intramural pH in gastric mucosa.
TL;DR: The back-diffusion of CO2 generated by buffering HCI with NaHCO, in the stomach, is examined, its influence on the pH in the wall of the gastric mucosa is observed, and its effects with those of HCl are compared.
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The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog
TL;DR: The high cholesterol, egg yolk diet caused the secretion of an "abnormal bile" which led to precipitation of cholesterol from micellar solution, and the increased bile cholesterol relative to bile acid and phospholipid favored stone formation.
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The effect of dietary cholesterol on the composition of human bile.
TL;DR: The data suggest that high dietary cholesterol intake leads to formation of abnormal bile in which the cholesterol concentration exceeds the capacity of bile acids and phospholipids to hold it in micellar solution.
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Effect of bile salts on the ionic permeability of the esophageal mucosa and their role in the production of esophagitis.
TL;DR: The hypothesis that HCl, in concentrations secreted by the gastric mucosa, does not significantly penetrate or injure the esophageal mucosa unless its permeability to H+ is altered is tested.
References
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Destruction of the Gastric Mucosal Barrier by Detergents and Urea
TL;DR: The effects of natural and synthetic detergents and urea in breaking the gastric mucosal barrier were studied by irrigating the separated, vagally denervated pouches of the oxyntic glandular area of the dog stomach first with a test solution of 100 mm HCl + 54 mm NaCl, then with a solution of the detergent or urea, and again with the acid test solution.
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Increased reflux of bile into the stomach in patients with gastric ulcer.
TL;DR: It is suggested that reflux of bile into the stomach may be a causative factor in gastric ulcer or, if secondary to the presence of an ulcer, may delay healing.