Journal ArticleDOI
Measurements of Intestinal Permeability Using Low Molecular Weight Polyethylene Glycols (PEG 400): II. Application to normal and abnormal permeability states in man and animals
TLDR
Successful assessments of gastric, jejunal, ileal, and colonic permeability suggest that the PEG 400 technique has application to any area of the gastrointestinal tract.About:
This article is published in Gastroenterology.The article was published on 1977-08-01. It has received 232 citations till now. The article focuses on the topics: Intestinal permeability & Intestinal absorption.read more
Citations
More filters
Journal ArticleDOI
Intestinal permeability: an overview.
TL;DR: There is a need for integrated research into the basic mechanisms of regulatory control of the intestinal barrier function and the potential and possible shortcomings of noninvasive tests of intestinal permeability.
Journal ArticleDOI
Bisphosphonates: a review of their pharmacokinetic properties.
TL;DR: The half-life of bisphosphonates in bone is very long, ranging among different species from 1 to 10 years, depending largely on the rate of bone turnover, and the relative contribution of these two processes to overall plasma elimination differs significantly among bisph phosphonates.
Journal Article
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives
Daniel Hollander,Constance M. Vadheim,Edward Brettholz,Gloria M. Petersen,Thomas Delahunty,Jerome I. Rotter +5 more
TL;DR: The twofold increase in permeability of patients and their relatives indicates that the intestinal defect in the ability to exclude larger sized molecules is not secondary to clinically recognized intestinal inflammation, but is a primary defect that may be an etiologic factor in this disease.
Journal ArticleDOI
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives: A Possible Etiologic Factor
Daniel Hollander,Constance M. Vadheim,Edward Brettholz,Gloria M. Petersen,Thomas Delahunty,Jerome I. Rotter +5 more
TL;DR: In this paper, the authors used the marker polyethylene glycol-400 ingested with a standard meal to assess the intestinal permeability of patients with Crohn's disease and their unaffected relatives.
Journal Article
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development
Jiunn H. Lin,Anthony Y. H. Lu +1 more
TL;DR: Drug research encompasses several diverse disciplines united by a common goal, namely the development of novel therapeutic agents, and can be divided functionally into two stages: discovery and development.
References
More filters
Journal ArticleDOI
Destruction of the Gastric Mucosal Barrier by Detergents and Urea
TL;DR: The effects of natural and synthetic detergents and urea in breaking the gastric mucosal barrier were studied by irrigating the separated, vagally denervated pouches of the oxyntic glandular area of the dog stomach first with a test solution of 100 mm HCl + 54 mm NaCl, then with a solution of the detergent or urea, and again with the acid test solution.
Journal ArticleDOI
Permeability characteristics of the human small intestine.
TL;DR: The hypothesis that mucosal cell membranes are interspersed with water-filled pores, through which small molecules can diffuse, is tested in the small intestine of the rat and results support the thesis that these molecules are absorbed by diffusion through water- filled pores.
Journal ArticleDOI
Increased reflux of bile into the stomach in patients with gastric ulcer.
TL;DR: It is suggested that reflux of bile into the stomach may be a causative factor in gastric ulcer or, if secondary to the presence of an ulcer, may delay healing.
Journal ArticleDOI
Measurements of Intestinal Permeability Using Low Molecular Weight Polyethylene Glycols (PEG 400): I. Chemical analysis and biological properties of PEG 400
TL;DR: In this paper, a new approach to the measurement of intestinal permeability in man has been developed, using low molecular weight polyethylene glycol (PEG 400) as probe molecules.
Journal ArticleDOI
Water and Solute Movement in the Small Intestine of Patients with Sprue
TL;DR: The finding that erythritol and L-xylose are essentially non-absorbable in small bowel involved with sprue, which indicates that the jejunal mucosa of these patients was in a secretory state with respect to water and electrolytes.