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Effect of few neuroleptic phytochemical agents on the serotonin content in mouse brain

Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats.

Genus Alstonia is comprised of around 155 species throughout the world. Phytochemical screening of Alstonia genus has demonstrated the presence of diverse phytochemicals that include at least 800 distinct metabolites. The main classes of metabolites are alkaloids, iridoids, flavonoids, fatty acids, etc. Secondary metabolites from this genus also bring positive results when employed as anti-cancer, anti-spasmodic, antitussive, antiarthritic, antioxidant, etc. Alstonia boonei is listed as an antimalarial drug in African pharmacopoeia. In China, a formulation consists of A. scholaris leaves—Dengtaiye tablets are used for the treatment of cough and fever symptoms. Recently, A. scholaris leaves-derived indole alkaloids have been registered as an investigational new botanical drug (No. 2011L01436) and China Food and Drug Administration (CFDA) has approved its phase I/II clinical trials for the treatment of respiratory diseases. Pharmacokinetic and safety analysis of this botanical drug in healthy human subjects have revealed a safe profile under the dose regimen experiment. Apart from that, strictamine, an indole alkaloid isolated from A. scholaris exhibited a similar in vitro antiviral activity to that of acyclovir. The present chapter is mainly focused on the critical analysis of various secondary metabolites isolated from Alstonia (approximately 15 species). Apart from that, pharmacological, toxicological and intellectual property rights studies have also been included.

Pharmaceutical Application of Bio-actives from Alstonia Genus: Current Findings and Future Directions

The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog.

welches bei doppe l te r F r equenz noch deut l ich sis A e r k a n n t wurde u n d n u t bei t ie feren F r e q u e n z e n einen ao -a r t i gen Charak te r a n n a h m . Mit dieser S tabi l i t~ t des A in g u t e m E~nklang s t e h t die Beobach±ung ~ , dab re ine TSne im a l lgemeinen nur sehr sehwer ffir ein A geha l ten werden . Der F o r m a n t sche in t bei der Beur te i tung des A d e m n a c h n i ch t ganz die Rol le zu spielen, die m a n e r w a r t e t ha t t e . E ine solche Ausnahmes t e l l ung des A h a t GaASS~AN~ ~ schon 1877 b e o b a c h t e t , , E s bes i t z t \" , nach ibm, , ,der Vokal a keinen charak te r i s t i schen , die ande ren f iberwiegenden Ober ton , sondern fiir ihn is t die ganze Reihe der Ober t6ne his zur 3. Ok tave des G r u n d t o n s eharak te r i s t i sch , und in diesem Sinne gil t fiir diesen Vokal das . . . Gesetz, dab je hSher der G r u n d t o n Iist, des to hSher s u c h die mi t k l ingenden Ober t6ne we rden . \" KOHL~R ~ muBte ebenfal ls se inerzei t zugeben, dab be im A n ich t ein ausgezeichneter P u n k t allein den A-Charak te r mach t , sonde rn alle Tei l tSne zusammen, die eine a -Valenz besi tzen. Bei den t ibrigen Vokalen konn t en wi t an den mi t ve r~nder t e r Geschwindigkei t l au fenden Gramm o p h o n p l a t t e n ~hnliche B e o b a c h t u n g e n machen . Sie veranlaBten uns, s u c h die bere i t s sehr wei t gehend e rweich te Abso lu t theor i e in ihrer AussehlieBlichkeit aufzugeben u n d so~voht den abso lu ten wie den re la t iven F a k t o r e n einen Antei l bei der Voka lb i ldung zuzuges tehen. E ine solche Verb indung yon Absolut u n d Re la t iv theo r i e h a t schon AU~B~CH ~ versucht . , ,Alle K1Enge, insb e s o n d e r e die Vokale der menseh l i chen S t i m m e u n d S p r a c h e , s ind\" , n a c h ihm, , , zu def inieren als die Folge des Zusammensch lusses zweier Momente , eines r e l a t iven und eines abso lu ten . \" Der Antei l

Die untere Explosionsgrenze der Gemische von schwerem Wasserstoff mit Luft

Villalstonine: Its effect on the general circulation

Pharmacological screening of Valeriana Wallichi D.C., Lallementia royleana benth, Breynia rhamnoides muell-arg and evolvulus numularians for sedative and anticonvulsive principles

Effect of few neuroleptic phytochemical agents on the serotonin content in mouse brain

Citations

Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats.

Pharmaceutical Application of Bio-actives from Alstonia Genus: Current Findings and Future Directions

References

The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog.

Die untere Explosionsgrenze der Gemische von schwerem Wasserstoff mit Luft

Villalstonine: Its effect on the general circulation

Pharmacological screening of Valeriana Wallichi D.C., Lallementia royleana benth, Breynia rhamnoides muell-arg and evolvulus numularians for sedative and anticonvulsive principles

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