Open AccessJournal Article
Effect of intermittent ventilation on pulmonary hypertension in chronic respiratory failure
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TLDR
In contrast to the COPD group in patients with chronic respiratory failure due to thoracic restriction nocturnal mechanical ventilation causes substantial reduction in pulmonary artery pressure after a one year application.Abstract:
Intermittent non-invasive (or nocturnal mechanical ventilation) eliminates symptoms of hypoventilation and improves gas exchange in patients with chronic respiratory failure. Performing right heart catheterisation we studied the influence of nocturnal mechanical ventilation on pulmonary hemodynamics. We investigated 20 patients with restrictive thoracic diseases (Post-TBC: n = 9, scoliosis: n = 11, PaCO2: 59.8 +/- 7.6 mmHg) and 13 patients with COPD (n = 13, PaCO2: 58.5 +/- 7.8 mmHg). All patients were mechanically ventilated in controlled mode. During the study the medication was not changed; COPD patients with long-term oxygen maintained this therapy. Right-heart catheterisation was performed immediately before and after 1 year nocturnal mechanical ventilation. In patients with thoracic restriction NMV induced a marked reduction of pulmonary artery pressure (PAP) from 33.2 +/- 10.0 mmHg before to 24.8 +/- 6.2 mmHg after 1 year nocturnal mechanical ventilation. In the COPD group PAP increased from 25.3 +/- 6.0 mmHg before to 27.5 +/- 6.0 mmHg after 1 year nocturnal mechanical ventilation. In contrast to the COPD group in patients with chronic respiratory failure due to thoracic restriction nocturnal mechanical ventilation causes substantial reduction in pulmonary artery pressure after a one year application.read more
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Journal ArticleDOI
Pulmonary hypertension due to lung diseases: Updated recommendations from the Cologne Consensus Conference 2018.
Horst Olschewski,Jürgen Behr,H Bremer,Martin Claussen,Philipp Douschan,Michael Halank,Matthias Held,Marius M. Hoeper,S Holt,Hans Klose,Stephan Krüger,Tobias J. Lange,Frank Reichenberger,Dirk Skowasch,Silvia Ulrich,Heinrike Wilkens,Werner Seeger +16 more
TL;DR: The 2018 updated recommendations of the PH working group are summarized in the present paper and include the diagnosis and treatment of PH in patients with chronic lung disease and the severity of both PH and the underlying lung disease.
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