Journal ArticleDOI
Effect of plasma from premenstrual syndrome and control patients on human platelet and rat brain synaptosome monoamine oxidase B activity.
TLDR
The results indicate that although human plasma contains endogenous substances which inhibit MAO activity, alterations in their concentration are probably not responsible for the previously reported transient changes in plateletMAO activity in PMS.Abstract:
The present study determined the kinetic properties of platelet monoamine oxidase (MAO) in patients with premenstrual syndrome (PMS) and control subjects during the pre- and postmenstrual intervals. In addition, we investigated the effects of plasma obtained during the pre- and postmenstrual intervals from both subject groups on MAO activity in washed human platelets and rat brain synaptosomes. The Vmax of platelet MAO in postmenstrual PMS patients was significantly less than that during the premenstrual phase. Plasma from both subject groups (10–100 µl) inhibited platelet and synaptosomal MAO in a dose-dependent manner to approximately the same degree at each time interval. The results indicate that although human plasma contains endogenous substances which inhibit MAO activity, alterations in their concentration are probably not responsible for the previously reported transient changes in platelet MAO activity in PMS.read more
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Behavioral and biochemical studies of dichloromethane fraction from the Areca catechu nut.
Ahsana Dar,Shagufta Khatoon +1 more
TL;DR: The dichloromethane fraction from Areca catechu was found to inhibit monoamine oxidase type A isolated from the rat brain with an IC50 of 665 +/- 65.1 microg/ml, suggesting that the dichlorometrichane fractions possesses antidepressant property via MAO-A inhibition.
Journal ArticleDOI
Synthesis and Biological Screening of 2‐Substituted 5,6‐Dihydro‐5‐oxo‐ 4H‐1,3,4‐oxadiazine‐4‐propanenitriles and of Their Intermediates
Khalid Mohammed Khan,Shagufta Rahat,Muhammad Iqbal Choudhary,Atta-ur-Rahman,Usman Ghani,Shahnaz Perveen,Shagufta Khatoon,Ahsana Dar,Abdul Malik +8 more
TL;DR: In this article, the effect of substituents on biological activities of electron-rich N-containing heterocycles was evaluated for antibacterial, antifungal, and enzyme-inhibition activities.
Journal ArticleDOI
Metabolism and menstrual cycle rhythmicity of serotonin in primary headaches.
TL;DR: The pattern of menstrual cycle‐related fluctuations in platelet serotonin levels were similar in female patients with tension headache and in controls, with a maximum value in the follicular phase, and in both migraine groups, in contrast, the peak occurred in the ovulatory phase.
Journal ArticleDOI
Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females.
Yasuhiro Ito,Tadayuki Iida,Yuumi Yamamura,Mayu Teramura,Yasushi Nakagami,Kaoru Kawai,Yoichi Nagamura,Ryoji Teradaira +7 more
TL;DR: Comparisons of salivary melatonin levels with different factors including quality of sleep, state and trait anxieties, and depression, were conducted to examine whether there is a relationship between melatonin, presumably associated with sleep, and psychological stress.