Institution
Suzuka University of Medical Science
Education•Suzuka, Japan•
About: Suzuka University of Medical Science is a education organization based out in Suzuka, Japan. It is known for research contribution in the topics: DNA damage & Diabetes mellitus. The organization has 697 authors who have published 1133 publications receiving 20254 citations. The organization is also known as: Suzuka iryō Kagaku Daigaku.
Topics: DNA damage, Diabetes mellitus, Cancer, Inflammation, DNA
Papers published on a yearly basis
Papers
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TL;DR: A review of surface modification techniques for polymers with graft chains can be found in this paper, focusing on grafting methods as well as the structure and function of grafted surfaces.
622 citations
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TL;DR: In this article, a review of the role of reactive oxygen and nitrogen species in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer, is presented.
Abstract: Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurodegenerative diseases and inflammation-related cancer. Our recent studies identifying and characterizing carbonylated proteins reveal oxidative damage to heat shock proteins in neurodegenerative disease models and inflammation-related cancer, suggesting dysfunction in their antioxidative properties. In neurodegenerative diseases, DNA damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. Immunohistochemical analyses showed co-localization of oxidative/nitrative DNA lesions and stemness markers in the cells of inflammation-related cancers. Here, we review oxidative stress and its significant roles in neurodegenerative diseases and cancer.
318 citations
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TL;DR: In this article, a specific peak appeared at a low molecular weight around 1×10 4 in gel permeation chromatography spectra of hydrolyzed poly( l -lactide) (PLLA) film, irrespective of the thermal history of the PLLA film.
280 citations
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TL;DR: Results indicate that BMCs seeded onto a biodegradable scaffold to establish tissue-engineered vascular autografts (TEVAs) is an ideal strategy, and present strong evidence for the justification and validity of the protocol in clinical trials of tissue engineering.
277 citations
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TL;DR: CHCHD2 mutations are associated with, and might be a cause of, autosomal dominant Parkinson's disease, and further functional studies are needed to understand how mutant CHCHD 2 might play a part in the pathophysiology of Parkinson's Disease.
Abstract: Summary Background Identification of causative genes in mendelian forms of Parkinson's disease is valuable for understanding the cause of the disease. We did genetic studies in a Japanese family with autosomal dominant Parkinson's disease to identify novel causative genes. Methods We did a genome-wide linkage analysis on eight affected and five unaffected individuals from a family with autosomal dominant Parkinson's disease (family A). Subsequently, we did exome sequencing on three patients and whole-genome sequencing on one patient in family A. Variants were validated by Sanger sequencing in samples from patients with autosomal dominant Parkinson's disease, patients with sporadic Parkinson's disease, and controls. Participants were identified from the DNA bank of the Comprehensive Genetic Study on Parkinson's Disease and Related Disorders (Juntendo University School of Medicine, Tokyo, Japan) and were classified according to clinical information obtained by neurologists. Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. We used the Fisher's exact test to calculate the significance of allele frequencies between patients with sporadic Parkinson's disease and unaffected controls, and we calculated odds ratios and 95% CIs of minor alleles. Findings We identified a missense mutation ( CHCHD2 , 182C>T, Thr61Ile) in family A by next-generation sequencing. We obtained samples from a further 340 index patients with autosomal dominant Parkinson's disease, 517 patients with sporadic Parkinson's disease, and 559 controls. Three CHCHD2 mutations in four of 341 index cases from independent families with autosomal dominant Parkinson's disease were detected by CHCHD2 mutation screening: 182C>T (Thr61Ile), 434G>A (Arg145Gln), and 300+5G>A. Two single nucleotide variants (−9T>G and 5C>T) in CHCHD2 were confirmed to have different frequencies between sporadic Parkinson's disease and controls, with odds ratios of 2·51 (95% CI 1·48–4·24; p=0·0004) and 4·69 (1·59–13·83, p=0·0025), respectively. One single nucleotide polymorphism (rs816411) was found in CHCHD2 from a previously reported genome-wide association study; however, there was no significant difference in its frequency between patients with Parkinson's disease and controls in a previously reported genome-wide association study (odds ratio 1·17, 95% CI 0·96–1·19; p=0·22). In SH-SY5Y cells, the 300+5G>A mutation but not the other two mutations caused exon 2 skipping. Interpretation CHCHD2 mutations are associated with, and might be a cause of, autosomal dominant Parkinson's disease. Further genetic studies in other populations are needed to confirm the pathogenicity of CHCHD2 mutations in autosomal dominant Parkinson's disease and susceptibility for sporadic Parkinson's disease, and further functional studies are needed to understand how mutant CHCHD2 might play a part in the pathophysiology of Parkinson's disease. Funding Japan Society for the Promotion of Science; Japanese Ministry of Education, Culture, Sports, Science and Technology; Japanese Ministry of Health, Labour and Welfare; Takeda Scientific Foundation; Cell Science Research Foundation; and Nakajima Foundation.
267 citations
Authors
Showing all 699 results
Name | H-index | Papers | Citations |
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Yoshito Ikada | 91 | 484 | 32434 |
Yasuhiko Tabata | 85 | 442 | 25211 |
Shosuke Kawanishi | 73 | 279 | 15542 |
Koichi Tanaka | 73 | 376 | 18730 |
Yutaka Seino | 70 | 500 | 20570 |
Yuichiro Yamada | 58 | 216 | 10786 |
Hiromu Sakurai | 55 | 260 | 9869 |
Yusuke Hiraku | 49 | 150 | 7238 |
Koji Suzuki | 45 | 241 | 6938 |
Hiroo Iwata | 45 | 159 | 7153 |
Hiroji Aiba | 42 | 63 | 5544 |
Kiyoshi Matsumura | 42 | 118 | 6377 |
Taizo Shiraishi | 41 | 178 | 5127 |
Nobuo Ohta | 40 | 185 | 4499 |
Ning Ma | 39 | 129 | 4778 |