Effects of combinations of ethanolic extracts of Blighia sapida and Xylopia aethiopica on progesterone, estradiol and lipid profile levels in pregnant rabbits
Odesanmi Os,Ayepola Olayemi,Omotosho Oe,Olubanke Olujoke Ogunlana,Frank Onwuka,Nwankpa Promise +5 more
TLDR
The results suggest that ethanolic extracts of X. aethiopica alone or in combination with B. sapida may actually lead to termination of pregnancy due to reduction of progesterone and estradiol and there is increased risk of hypertriglyceridemia in the users of these plants.Abstract:
th to 25th day of gestation after which they were fasted for 18 h. Serum levels of reproductive hormones (progesterone and estradiol) and lipids (triglycerides, total cholesterol, LDL-cholesterol and HDLcholesterol) were determined at the end of the treatment. Results showed significant reductions (p < 0.05) in progesterone and estradiol levels, significant elevations of triglycerides (p < 0.05) and no statistically significant differences (p < 0.05) in the levels of total cholesterol in all the treated groups compared with the control (group A). There was a statistically significant reduction (p < 0.05) in the levels of HDL-cholesterol in Group B, a significant increase in group C and no significant reduction in group D compared with the control (group A). The levels of LDL-cholesterol in all the treated groups did not differ significantly (p < 0.05) from the control (group A). The results suggest that ethanolic extracts of X. aethiopica alone or in combination with B. sapida may actually lead to termination of pregnancy due to reduction of progesterone and estradiol. The results also suggest that there is increased risk of hypertriglyceridemia in the users of these plants but this may not predispose them to arteriosclerosis because of the insignificant differences in the levels of LDL-cholesterol in all the treated groups compared with the control.read more
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Dissertation
A preliminary study of the antiproliferative properties of crude blighia sapida seeds extracts on lung, prostate, skin, leukemic cancers and normal human liver cells
TL;DR: In this article, the medicinal capabilities of Blighia sapida seeds are investigated by evaluating the antioxidant and antiproliferative activities on, lung, prostate, skin, leukemic cancers and normal liver cells using methods such as GC-MS, MTT and Resazurin based cell viability assays and DPPH/FRAP assays.
References
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Journal ArticleDOI
Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
Book
Handbook of Medicinal Herbs, Second Edition
TL;DR: James A. Duke, Ph.D., retired from the United States Department of Agriculture (USDA) in 1995 after a 35-year career there and elsewhere as an economic botanist as mentioned in this paper.
Journal ArticleDOI
National Cholesterol Education Program
Richard A. Carleton,Johanna T. Dwyer,L. Finberg,J. A. Flora,DeWitt S. Goodman,Scott M. Grundy,Stephen Havas,G. T. Hunter,David Kritchevsky,Ronald M. Lauer,Russell V. Luepker,Amelie G. Ramirez,L. Van Horn,William B. Stason,Joseph Iii. Stokes,James I. Cleeman,Nancy D. Ernst,William T. Friedewald,Basil M. Rifkind +18 more
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Simultaneous radioimmunoassay of plasma FSH, LH, progesterone, 17-hydroxyprogesterone, and estradiol-17 beta during the menstrual cycle.
TL;DR: The data suggest that in women, there is a relationship between the steroids 17-OHP and E2, and the mid-cycle peaks were observed in every normal cycle studied.
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