Ganesh Shankar Vidyarthi Memorial Medical College

About: Ganesh Shankar Vidyarthi Memorial Medical College is a education organization based out in Kanpur, India. It is known for research contribution in the topics: Population & Vitamin D and neurology. The organization has 571 authors who have published 407 publications receiving 2747 citations. The organization is also known as: GSVMMC & GSVM Medical College.

Randomized study of intravenous valproate and phenytoin in status epilepticus

Abstract: Summary Introduction The evidence based data to guide management in patients of benzodiazepine refractory status epilepticus (SE) is still lacking. We conducted a randomized study to evaluate the comparative effect of intravenous (IV) phenytoin and intravenous valproate (IV VA) in patients of benzodiazepine refractory SE. Background and methods Hundred, age and sex matched, patients of benzodiazepine refractory SE were randomly divided into Group A (50 patients), treated with IV VA and Group B (50 patients) treated with IV phenytoin. Twelve patients, in whom SE was not controlled with a single drug, were switched over to the other group. Treatment was considered successful when all motor or EEG seizure activity ceased within 20min after the beginning of the drug infusion and no return of seizure activity during the next 12h. Secondary study end points were adverse events to treatment, in-hospital complications and the neurological outcome at discharge. Results In this study, IV VA was successful in 88% and IV phenytoin in 84% ( p >0.05) of patients of SE with a significantly better response in patients of SE p p >0.05). There were no differences among the treatments with respect to recurrence after 12-h study period or the outcome at 7 days. Conclusion IV VA is as effective as IV phenytoin. It is easy to use, better tolerated and can be used as an alternative to IV phenytoin in patients of benzodiazepine refractory SE, especially in patients of cardio-respiratory disease. The better outcome in patients having shorter duration of SE (

Interstitial Lung Disease in India. Results of a Prospective Registry

Abstract: Rationale: Interstitial lung disease (ILD) is a heterogeneous group of acute and chronic inflammatory and fibrotic lung diseases. Existing ILD registries have had variable findings. Little is known about the clinical profile of ILDs in India.Objectives: To characterize new-onset ILDs in India by creating a prospective ILD using multidisciplinary discussion (MDD) to validate diagnoses.Methods: Adult patients of Indian origin living in India with new-onset ILD (27 centers, 19 Indian cities, March 2012–June 2015) without malignancy or infection were included. All had connective tissue disease (CTD) serologies, spirometry, and high-resolution computed tomography chest. ILD pattern was defined by high-resolution computed tomography images. Three groups independently made diagnoses after review of clinical data including that from prompted case report forms: local site investigators, ILD experts at the National Data Coordinating Center (NDCC; Jaipur, India) with MDD, and experienced ILD experts at the Center fo...

A randomised controlled trial of high-dose isoniazid adjuvant therapy for multidrug-resistant tuberculosis.

Abstract: CONTEXTE: Hopital de soins tertiaires a Kanpur, Inde OBJECTIF: On reconnait de plus en plus la necessite d'un protocole standardise de traitement pour la tuberculose a germes multiresistants (TB-MDR) dans les pays a ressources limitees Nous avons mene une etude pour evaluer l'efficience d'une forte dose d'isoniazide (INH) (16-18 mg/kg) comme adjuvant a un traitement de seconde ligne dans des cas documentes de TB-MDR SCHEMA:Il s'agit d'un essai controle randomise en double aveugle avec trois bras de traitement-une forte dose d'INH, une dose normale d'INH et un placebo-en complement des medicaments de deuxieme ligne Les resultats principaux de l'etude ont ete la duree avant negativation des cultures de crachats et la proportion de sujets a culture negative 6 mois apres le debut du traitement Les resultats secondaires ont ete l'amelioration radiologique un an apres le traitement et l'apparition d'une toxicite RESULTATS : Apres ajustement pour les facteurs confondants potentiels, les sujets ayant recu de l'INH a forte dose ont eu des crachats negatifs 2,38 fois plus rapidement que ceux qui ne l'ont pas recu (IC95% 1,45-3,91 ; P = 0,001) et ont eu 2,37 fois plus de chances d'avoir une expectoration negative a 6 mois (IC95% 1,46-3,84 ; P < 0,001) Chez ces sujets, l'amelioration radiologique a ete significativement meilleure, sans accroissement du risque de toxicite de l'INH CONCLUSION: Dans les contextes a faibles ressources ou un protocole therapeutique standardise est utilise pour la TB-MDR, ce protocole peut etre ameliore de facon significative par l'inclusion d'une forte dose d'INH comme adjuvant

Investigation of geo-spatial hotspots for the occurrence of tuberculosis in Almora district, India, using GIS and spatial scan statistic.

Abstract: The World Health Organization has declared tuberculosis a global emergency in 1993. It has been estimated that one third of the world population is infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. The emergence of TB/HIV co-infection poses an additional challenge for the control of tuberculosis throughout the world. The World Health Organization is supporting many developing countries to eradicate tuberculosis. It is an agony that one fifth of the tuberculosis patients worldwide are in India. The eradication of tuberculosis is the greatest public health challenge for this developing country. The aim of the present population based study on Mycobacterium tuberculosis is to test a large set of tuberculosis cases for the presence of statistically significant geographical clusters. A spatial scan statistic is used to identify purely spatial and space-time clusters of tuberculosis. Significant (p < 0.05 for primary clusters and p < 0.1 for secondary clusters) high rate spatial and space-time clusters were identified in three areas of the district. There is sufficient evidence about the existence of statistically significant tuberculosis clusters in Almora district of Uttaranchal, India. The spatial scan statistics methodology used in this study has a potential use in surveillance of tuberculosis for detecting the true clusters of the disease.